Nerve Growth Factor antibody (ABIN7262081) | 루미젠코리아
Antibodies-online
The antibody has minimal cross-reactivity with BDNF NT-3 and NT-4/5. Antibodies -20°C
제품 사양
| Cat No | ABIN7262081 |
|---|---|
| Manufacturer | Antibodies-online |
| Reactivity | The antibody has minimal cross-reactivity with BDNF, NT-3, and NT-4/5. |
| Target | Nerve growth factor,The neurotrophins ("neuro" means nerve and "trophe" means nutrient) are a family of soluble, basic growth factors which regulate neuronal development, maintenance, survival and death in the CNS and the PNS.1 NGF, the first member of the family to be discovered, was originally purified as a factor able to support survival of sympathetic and sensory spinal neurons in culture.2 It is synthesized and secreted by sympathetic and sensory target organs and provides trophic support to neurons as they reach their final target.3 Neurotrophin secretion also increases in the nervous system following injury. Schwann cells, fibroblasts, and activated mast cells normally synthesize NGF constitutively, however direct trauma and induced cytokines combine to increase neurotrophin production in these cells after injury.4 NGF is purified in three forms: the 7S, 2.5S and β. The 7S, 130 kDa, form occurs naturally in mouse submaxillary glands, and is a multimeric protein composed of two α, one β and two γ subunits. The name is derived from its sedimentation co-efficient, 7S. The biologically active subunit is the β, which is a 26 kDa dimer composed of two identical 120 amino acid chains held together by hydrophobic interactions.5 The 2.5S form is 9 amino acids shorter than the β form, because of proteolysis that occurs during the purification process.6 The structural hallmark of all the neurotrophins is the characteristic arrangement of the disulfide bridges known as the cysteine knot, which has been found in other growth factors such as PDGF.7 There is a 95.8 % homology between the rat and mouse forms, and a 85 % homology between the human and mouse.NGF has been shown to regulate neuronal survival, development function and plasticity.8 Recently, involvement of NGF in processes not involving neuronal cells has been shown, such as asthma,9 psoriasis10 and wound healing.11 The biological effects of NGF are mediated by two receptors: TrkA, which is specific for NGF, and p75, which binds all the neurotrophins.12 |
| Storage | -20°C |
Datasheet PDF Provided by Antibodies-online
상세 설명
이 항체는 신경세포의 생존과 분화 및 가소성 조절에 핵심적인 역할을 하는 신경성장인자(NGF)를 선택적으로 검출합니다. BDNF, NT-3 등 유사 단백질과의 교차 반응을 최소화하여 데이터의 신뢰성을 높였습니다. 신경계 발달 연구뿐 아니라 상처 치유 및 염증 반응 분석 등 다양한 실험에 최적화되어 있습니다.
This specific antibody detects Nerve Growth Factor (NGF) across multiple species to study neuronal survival and plasticity with minimal cross-reactivity to other neurotrophin family members.
Nerve Growth Factor antibody (ABIN7262081)은 루미젠코리아를 통해 국내 구매 및 견적이 가능합니다.
제조사: Antibodies-online | 분류: Antibodies
보관 조건: 4 °C,-20 °C | 배송 조건: –
제조사: Antibodies-online | 분류: Antibodies
보관 조건: 4 °C,-20 °C | 배송 조건: –