Caspase 8 antibody (AA 411-482) (ABIN724205) | 루미젠코리아
Antibodies-online
Human Monkey Mouse Pig Rat Sheep Western Blotting Antibodies 100 μL -20°C
제품 사양
| Cat No | ABIN724205 |
|---|---|
| Manufacturer | Antibodies-online |
| Reactivity | Human, Monkey, Mouse, Pig, Rat, Sheep |
| Target | Synonyms: MACH, Mch5, FLICE, CASP-8, Caspase-8, Casp8Background: Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP1. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. |
| Assay Method | Western Blotting |
| Size | 100 μL |
| Storage | -20°C |
Datasheet PDF Provided by Antibodies-online
상세 설명
이 항체는 세포 사멸의 주요 개시 효소인 Caspase-8의 411-482 아미노산 부위를 특이적으로 인식합니다. 인간을 포함하여 마우스, 쥐 등 다양한 포유류 시료에서 Western Blot을 통한 단백질 발현 분석에 최적화되어 있습니다. 외인성 세포 사멸 경로 및 신호 전달 기전 연구에 매우 유용한 도구입니다.
This antibody targets the 411-482 region of the Caspase-8 initiator protease, providing reliable Western Blot detection in human, mouse, rat, and other mammalian species for apoptosis studies.
Caspase 8 antibody (AA 411-482) (ABIN724205)은 루미젠코리아를 통해 국내 구매 및 견적이 가능합니다.
제조사: Antibodies-online | 분류: Antibodies
보관 조건: 4 °C,-20 °C | 배송 조건: –
제조사: Antibodies-online | 분류: Antibodies
보관 조건: 4 °C,-20 °C | 배송 조건: –