CD3 antibody (ABIN638434) | 루미젠코리아
Antibodies-online
Human Non-Human Primates Antibodies 100 μg
제품 사양
| Cat No | ABIN638434 |
|---|---|
| Manufacturer | Antibodies-online |
| Reactivity | Human, Non-Human Primates |
| Target | CD3 antigen, epsilon polypeptide,CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82 % of normal peripheral blood lymphocytes, 65-85 % of thymocytes and Purkynje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.,CD3E, T3E, TCRE |
| Size | 100 μg |
| Storage | 4 °C |
Datasheet PDF Provided by Antibodies-online
상세 설명
CD3 항체는 T 세포 수용체(TCR) 복합체의 핵심 구성 요소인 CD3 epsilon 단백질을 선택적으로 인식하여 T 세포의 분화 및 활성화를 연구하는 데 활용됩니다. 인간 및 비인간 영장류 샘플에서 면역 세포 프로파일링과 세포 내 신호 전달 분석을 수행하는 연구자에게 필수적인 도구입니다.
This monoclonal antibody targets the CD3 epsilon subunit of the TCR complex in human and non-human primates, enabling T cell identification and activation studies in flow cytometry and IHC.
타겟 유전자 정보 — T cell receptor alpha variable 6-3
이 유전자는 인간 TRAV9-2 (T 세포 수용체 알파 가변 9-2)의 상동 유전자입니다.
출처: NCBI Gene Database
CD3 antibody (ABIN638434)은 루미젠코리아를 통해 국내 구매 및 견적이 가능합니다.
제조사: Antibodies-online | 분류: Antibodies
보관 조건: 4 °C | 배송 조건: –
제조사: Antibodies-online | 분류: Antibodies
보관 조건: 4 °C | 배송 조건: –