CD3 antibody (ABIN638428) | 루미젠코리아
Antibodies-online
Human Antibodies 100 μg
제품 사양
| Cat No | ABIN638428 |
|---|---|
| Manufacturer | Antibodies-online |
| Reactivity | Human |
| Target | CD3 antigen, epsilon polypeptide,CD3 complex is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82 % of normal peripheral blood lymphocytes, 65-85 % of thymocytes and Purkynje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases.,CD3E, T3E, TCRE |
| Size | 100 μg |
| Storage | 4 °C |
Datasheet PDF Provided by Antibodies-online
상세 설명
본 제품은 인간 T세포 표면의 CD3 epsilon 서브유닛을 특이적으로 인식하여 T세포의 식별 및 계통 분석에 최적화된 항체입니다. 유세포 분석과 조직 면역 염색을 포함한 다양한 실험에서 활용 가능하며, B세포나 NK세포와의 교차 반응 없이 높은 선택성을 제공합니다.
This human-reactive antibody targets the CD3 epsilon subunit to facilitate precise T-cell identification and signal transduction analysis in flow cytometry and immunohistochemistry assays.
타겟 유전자 정보 — T cell receptor alpha variable 6-3
이 유전자는 인간 TRAV9-2 (T 세포 수용체 알파 가변 9-2)의 상동 유전자입니다.
출처: NCBI Gene Database
CD3 antibody (ABIN638428)은 루미젠코리아를 통해 국내 구매 및 견적이 가능합니다.
제조사: Antibodies-online | 분류: Antibodies
보관 조건: 4 °C | 배송 조건: –
제조사: Antibodies-online | 분류: Antibodies
보관 조건: 4 °C | 배송 조건: –