ZEB1 — 카탈로그 59건
Gene ZEB1
NCBI Gene 6935
취급 제조사 4곳
국내 소싱 가능
59건
유전자 개요
ZEB1은 징크핑거(zinc finger) 전사인자(transcription factor)를 암호화하며, 이 단백질은 인터루킨-2(interleukin 2)의 전사 억제에 관여하는 것으로 추정된다. 이 유전자의 변이는 후부 다형 각막이상증 3형(posterior polymorphous corneal dystrophy-3) 및 후기 발병 Fuchs 내피 각막이상증과 연관되어 있다. 서로 다른 아이소폼(isoform)을 암호화하는 선택적 스플라이싱 전사체 변이체들이 보고되었다.
Interleukin-4 and Interleukin-13 signalingNegative Regulation of CDH1 Gene TranscriptionRegulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
Fuchs endothelial corneal dystrophyposterior polymorphous corneal dystrophyposterior polymorphous corneal dystrophy 3corneal dystrophyserum gamma-glutamyl transferase measurementbody heightbody weightcorneal dystrophy, Fuchs endothelial, 6
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Pleiotropic Roles for ZEB1 in Cancer. · Cancer Res (2018)Exosome-mediated miR-144-3p promotes ferroptosis to inhibit osteosarcoma proliferation, migration, and invasion through regulating ZEB1. · Mol Cancer (2023)Zeb1-induced metabolic reprogramming of glycolysis is essential for macrophage polarization in breast cancer. · Cell Death Dis (2022)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
CDH1
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
SOX2
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
MITF
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
SERPINE1
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
EDIL3
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
ITGA2
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
PXN
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
PXDN
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition