YWHAZ — 카탈로그 68건
Gene YWHAZ
NCBI Gene 7534
국내 소싱 가능
68건
유전자 개요
YWHAZ가 암호화하는 단백질은 포스포세린(phosphoserine)을 함유한 단백질에 결합하여 신호 전달(signal transduction)을 매개하는 14-3-3 단백질 패밀리에 속하며, 식물과 포유류에 걸쳐 고도로 보존되어 마우스·랫드·양의 오솔로그(ortholog)와 99% 동일하다. 또한 IRS1 단백질과 상호작용하여 인슐린 감수성(insulin sensitivity) 조절에 관여할 가능성이 제기되며, 5’ UTR이 서로 다르지만 동일한 단백질을 암호화하는 여러 전사체 변이체(transcript variant)가 확인되었다.
Activation of BAD and translocation to mitochondria Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexDeactivation of the beta-catenin transactivating complexGP1b-IX-V activation signallingInterleukin-3, Interleukin-5 and GM-CSF signalingKSRP (KHSRP) binds and destabilizes mRNANOTCH4 Activation and Transmission of Signal to the NucleusNegative regulation of NOTCH4 signalingRHO GTPases activate PKNsRap1 signalling
platelet volumebody mass indexreticulocyte countreticulocyte amountchronotype measurementneurodegenerative diseaselean body massAbnormality of the skeletal system
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Mitochondria-targeting sequence, a multi-role sorting sequence recognized at all steps of protein import into mitochondria. · J Biochem (1998)GAPDH, 18S rRNA and YWHAZ are suitable endogenous reference genes for relative gene expression studies in placental tissues from human idiopathic fetal growth restriction. · Placenta (2008)KAT2A succinyltransferase activity-mediated 14-3-3ζ upregulation promotes β-catenin stabilization-dependent glycolysis and proliferation of pancreatic carcinoma cells. · Cancer Lett (2020)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
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