WRN — 카탈로그 28건
Gene WRN
NCBI Gene 7486
취급 제조사 3곳
국내 소싱 가능
28건
Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding functionDefective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding functionDefective homologous recombination repair (HRR) due to BRCA1 loss of functionG2/M DNA damage checkpointHDR through Homologous Recombination (HRR)HDR through Single Strand Annealing (SSA)Homologous DNA Pairing and Strand ExchangeImpaired BRCA2 binding to PALB2Impaired BRCA2 binding to RAD51Presynaptic phase of homologous DNA pairing and strand exchange
Werner syndromecancerhigh density lipoprotein cholesterol measurementcholesteryl ester measurementtype 2 diabetes mellitusintelligencemelanomaneutrophil count
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. · Science (2015)Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions. · Ageing Res Rev (2017)Repeat expansions confer WRN dependence in microsatellite-unstable cancers. · Nature (2020)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Biosynth | F502-131051-01 | 70R-35927 | WRN antibody (Ser1141) | Rabbit | Polyclonal | WRN antibody (Ser1141) detects endogenous levels of Werner Syndrome Helicase only when phosphorylated at serine 1141 | WB, ELISA | 0.1 mg | |
| MyBioSource | R247-213942-01 | MBS9608745 | WRN, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| ELK Biotechnology | T376-121290-01 | ES7518 | WRN (phospho Ser1141) rabbit pAb | Rabbit | Polyclonal | Human;Rat;Mouse; | WB;ELISA | 50μL |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
DNA2
Removal of the Flap Intermediate from the C-strand
BRCA1
Impaired BRCA2 binding to PALB2
ATM
Impaired BRCA2 binding to PALB2
BARD1
Impaired BRCA2 binding to PALB2
BRIP1
Impaired BRCA2 binding to PALB2
NBN
Impaired BRCA2 binding to PALB2
RAD50
Impaired BRCA2 binding to PALB2
TOP3A
Impaired BRCA2 binding to PALB2