WIF1 — 카탈로그 52건
Gene WIF1
NCBI Gene 11197
국내 소싱 가능
52건
유전자 개요
WIF1이 암호화하는 단백질은 배아 발생에 관여하는 세포외 신호분자인 WNT 단백질을 억제하는 기능을 한다. 이 단백질은 WNT 억제 인자(WNT inhibitory factor, WIF) 도메인 하나와 다섯 개의 표피 성장 인자(epidermal growth factor, EGF) 유사 도메인을 포함하며, 중배엽 분절(mesoderm segmentation)에 관여하는 것으로 여겨진다. 또한 종양 억제 유전자(tumor suppressor gene)로 기능하며, 다양한 암에서 후성유전적으로 침묵화되는 것으로 확인되었다.
Negative regulation of TCF-dependent signaling by WNT ligand antagonistsTCF dependent signaling in response to WNT
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데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease. · Ann Rheum Dis (2019)m(6)A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling. · Mol Cancer (2020)Aberrant oligodendroglial-vascular interactions disrupt the blood-brain barrier, triggering CNS inflammation. · Nat Neurosci (2019)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cusabio | T094-107300-01 | CSB-PA026113LA01HU | WIF1 Antibody | Rabbit | Polyclonal | Human | ELISA, IHC | 50μg, 100μg | |
| Biosynth | F502-103635-01 | 10R-2256 | WIF1 antibody | Mouse | Monoclonal | Human; Cross: Human | ELISA, IF, IHC, WB | 100 ul | |
| Cloud-Clone | T813-128115-01 | PAL826Hu01 | Polyclonal Antibody to WNT Inhibitory Factor 1 (WIF1) | Rabbit | Polyclonal | Human | WB | 100µl | |
| Cloud-Clone | T813-115774-01 | MAL826Hu21 | Monoclonal Antibody to WNT Inhibitory Factor 1 (WIF1) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-128116-01 | PAL826Ra01 | Polyclonal Antibody to WNT Inhibitory Factor 1 (WIF1) | Rabbit | Polyclonal | Rat | IHC | 100µl | |
| MyBioSource | R247-208594-01 | MBS9415482 | WIF1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | WB; IHC | 0.1 mL | |
| MyBioSource | R247-199691-01 | MBS9133023 | WIF1, Polyclonal Antibody | Rabbit | Polyclonal | Mouse, Rat | WB | 0.02 mL | |
| Biosynth | F502-139985-01 | 70R-9170 | WIF1 antibody | Rabbit | Polyclonal | Human; Cross: Predicted: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish | WB | 100 ul |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
DKK1
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DKK4
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WNT3A
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WNT5A
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SFRP2
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SOST
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SFRP1
Negative regulation of TCF-dependent signaling by WNT ligand antagonists