USP7 — 카탈로그 15건
Gene USP7
NCBI Gene 7874
국내 소싱 가능
15건
유전자 개요
이 유전자가 지정하는 단백질은 유비퀴틴일수소화효소(ubiquitinyl hydrolases)를 포함하는 peptidase C19 계열에 속한다. 이 단백질은 종양 억제 단백질인 p53과 엔도솜 단백질 재활용에 필수적인 WASH와 같은 표적 단백질을 탈유비퀴틴화(deubiquitinates)한다. 또한, 관련 과정에 관여하는 HDM2 및 TRIM27과 같은 단백질의 상반되는 유비퀴틴 연결효소(ubiquitin ligase) 활성에 길항 작용을 하여 표적 단백질들의 활성을 조절한다. 이 유전자의 돌연변이는 신경 발달 장애와 관련이 있는 것으로 보고되었다.
Dual incision in TC-NERFormation of TC-NER Pre-Incision ComplexGap-filling DNA repair synthesis and ligation in TC-NERRegulation of PTEN localizationRegulation of TP53 DegradationSynthesis of active ubiquitin: roles of E1 and E2 enzymesTranscription-Coupled Nucleotide Excision Repair (TC-NER)Ub-specific processing proteases
Hao-Fountain syndromeHao-Fountain syndrome due to USP7 mutationneurodegenerative diseaseplatelet countplatelet volumebody heightplatelet component distribution widthgenetic disorder
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer. · Mol Cancer (2020)Molecular basis of USP7 inhibition by selective small-molecule inhibitors. · Nature (2017)Ubiquitin-Specific Proteases (USPs) and Metabolic Disorders. · Int J Mol Sci (2023)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cusabio | T094-108527-01 | CSB-PA849973LA01HU | USP7 Antibody | Rabbit | Polyclonal | Human | ELISA, IHC, IF | 50μg, 100μg | |
| MyBioSource | R247-213826-01 | MBS9608138 | USP7, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; ELISA | 0.1 mL | |
| MyBioSource | R247-213678-01 | MBS9607584 | USP7, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| Biosynth | F502-106044-01 | 10R-6256 | USP7 antibody | Mouse | Monoclonal | Human; Cross: Human | IHC, WB | 100 ul | |
| Biosynth | F502-106045-01 | 10R-6257 | USP7 antibody | Mouse | Monoclonal | Human; Cross: Human | FC, IHC, WB | 100 ul | |
| Biosynth | F502-106043-01 | 10R-6255 | USP7 antibody | Mouse | Monoclonal | Human; Cross: Human | IHC, WB | 100 ul | |
| Biosynth | F502-106041-01 | 10R-6252 | USP7 antibody | Mouse | Monoclonal | Human; Cross: Human | IHC, WB | 100 ul | |
| Biosynth | F502-106042-01 | 10R-6254 | USP7 antibody | Mouse | Monoclonal | Human; Cross: Human | IHC, WB | 100 ul | |
| Cloud-Clone | T813-123397-01 | PAC255Hu01 | Polyclonal Antibody to Ubiquitin Specific Peptidase 7 (USP7) | Rabbit | Polyclonal | Human | IHC | 100µl | |
| MyBioSource | R247-113497-01 | MBS127538 | USP7, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | WB; IHC; IF | 0.02 mL | |
| MyBioSource | R247-199806-01 | MBS9133601 | USP7, Polyclonal Antibody | Rabbit | Polyclonal | Human, Rat | WB | ||
| Biosynth | F502-140458-01 | 70R-9662 | USP7 antibody | Rabbit | Polyclonal | Human, Rat; Cross: Predicted: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish | WB | 100 ul |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
UBB
Regulation of PTEN localization
PTEN
Regulation of PTEN localization
XIAP
Regulation of PTEN localization
NEDD4
Regulation of PTEN localization
PML
Regulation of PTEN localization
CDK7
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
ERCC6
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
GTF2H4
Transcription-Coupled Nucleotide Excision Repair (TC-NER)