UBE2S — 카탈로그 10건
Gene UBE2S
NCBI Gene 27338
취급 제조사 4곳
국내 소싱 가능
10건
유전자 개요
이 유전자는 유비퀴틴-결합 효소(ubiquitin-conjugating enzyme) 계열 단백질을 암호화한다. 이렇게 지정된 단백질은 유비퀴틴 활성화 효소(ubiquitin activating enzyme)의존적으로 유비퀴틴과 티올 에스테르 결합(thiol ester linkage)을 형성할 수 있으며, 이는 유비퀴틴 운반 단백질의 특징적인 성질이다.
APC-Cdc20 mediated degradation of Nek2AAPC/C:Cdc20 mediated degradation of Cyclin BAPC/C:Cdc20 mediated degradation of SecurinAPC/C:Cdc20 mediated degradation of mitotic proteinsAPC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1Aberrant regulation of mitotic exit in cancer due to RB1 defectsAntigen processing: Ubiquitination & Proteasome degradationAssembly of the pre-replicative complexAutodegradation of Cdh1 by Cdh1:APC/CCDK-mediated phosphorylation and removal of Cdc6
neurodegenerative diseasehepatocellular carcinomaneoplasmovarian cancertriglyceride measurementposterior cortical atrophybreast cancercancer
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) UBE2S interacting with TRIM28 in the nucleus accelerates cell cycle by ubiquitination of p27 to promote hepatocellular carcinoma development. · Signal Transduct Target Ther (2021)UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer. · Cell Death Dis (2023)UBE2S promotes the proliferation and survival of human lung adenocarcinoma cells. · BMB Rep (2018)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
UBE2C
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
UBE2D1
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
CDC23
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
UBB
APC/C:Cdc20 mediated degradation of Cyclin B
BUB1B
Inactivation of APC/C via direct inhibition of the APC/C complex
BUB3
Inactivation of APC/C via direct inhibition of the APC/C complex
CDK1
Phosphorylation of the APC/C
CCNB1
Phosphorylation of the APC/C