UBE2C — 카탈로그 46건
Gene UBE2C
NCBI Gene 11065
국내 소싱 가능
46건
유전자 개요
UBE2C는 E2 유비퀴틴 결합 효소(ubiquitin-conjugating enzyme) 계열의 구성원을 암호화하는 유전자다. 유비퀴틴(ubiquitin)에 의한 단백질 변형은 비정상적이거나 수명이 짧은 단백질을 분해 대상으로 지정하는 중요한 세포 기전으로, 유비퀴틴화(ubiquitination)에는 유비퀴틴 활성화 효소, 유비퀴틴 결합 효소, 유비퀴틴-단백질 연결효소(ubiquitin-protein ligase) 등 최소 세 부류의 효소가 관여한다. UBE2C가 암호화하는 단백질은 유사분열 사이클린(mitotic cyclin)의 분해와 세포 주기(cell cycle) 진행에 필요하며 암 진행에 관여할 가능성이 있고, 서로 다른 아이소폼(isoform)을 암호화하는 여러 전사체 변이체와 4, 14, 15, 18, 19번 염색체의 위유전자(pseudogene)가 보고되었다.
APC-Cdc20 mediated degradation of Nek2AAPC/C:Cdc20 mediated degradation of Cyclin BAPC/C:Cdc20 mediated degradation of SecurinAPC/C:Cdc20 mediated degradation of mitotic proteinsAPC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1Aberrant regulation of mitotic exit in cancer due to RB1 defectsAntigen processing: Ubiquitination & Proteasome degradationAssembly of the pre-replicative complexAutodegradation of Cdh1 by Cdh1:APC/CCDK-mediated phosphorylation and removal of Cdc6
neurodegenerative diseaseplatelet volumebody heighthepatocellular carcinomanon-small cell lung carcinomacancerneoplasmbreast cancer
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Lactate regulates cell cycle by remodelling the anaphase promoting complex. · Nature (2023)Delineating the dynamic evolution from preneoplasia to invasive lung adenocarcinoma by integrating single-cell RNA sequencing and spatial transcriptomics. · Exp Mol Med (2022)Ubiquitin-conjugating enzyme UBE2C: molecular biology, role in tumorigenesis, and potential as a biomarker. · Tumour Biol (2012)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cusabio | T094-109641-01 | CSB-RA025440MA1HU | UBE2C Recombinant Monoclonal Antibody | Mouse | Monoclonal | Human | ELISA, IHC, FC | 50μl, 100μl | |
| MyBioSource | R247-213792-01 | MBS9608015 | UBE2C, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; ELISA | 0.1 mL | |
| MyBioSource | R247-200648-01 | MBS9144625 | UBE2C, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB; IHC; IF; ICC; IP | 0.02 mL | |
| Biosynth | F502-124376-01 | 70R-21097 | UBE2C antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, IHC, WB | 50 ul | |
| Cloud-Clone | T813-114796-01 | MAE594Hu21 | Monoclonal Antibody to Ubiquitin Conjugating Enzyme E2C (UBE2C) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-125905-01 | PAE594Hu01 | Polyclonal Antibody to Ubiquitin Conjugating Enzyme E2C (UBE2C) | Rabbit | Polyclonal | Human | WB; ICC/IF | 100µl | |
| MyBioSource | R247-151213-01 | MBS4381571 | Ubiquitin-conjugating Enzyme E2C/UBCH10 (UBE2C), Monoclonal Antibody | Mouse | Monoclonal | Human | ELISA; Immunohistochemistry (IHC) Paraffin | 0.02 mg | |
| Biosynth | F502-136802-01 | 70R-5585 | UBE2C antibody | Rabbit | Polyclonal | UBE2C antibody was raised against the middle region of UBE2C; Cross: Human | WB | 100 ul | |
| Biosynth | F502-136804-01 | 70R-5587 | UBE2C antibody | Rabbit | Polyclonal | UBE2C antibody was raised against the N terminal of UBE2C; Cross: Human,Mouse,Rat | WB | 100 ul | |
| Biosynth | F502-136805-01 | 70R-5588 | UBE2C antibody | Rabbit | Polyclonal | UBE2C antibody was raised against the middle region of UBE2C; Cross: Human,Mouse | WB | 100 ul | |
| MyBioSource | R247-154666-01 | MBS476600 | UBE2C, Monoclonal Antibody | Mouse | Monoclonal | Human | WB; IHC | 0.1 mL |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
UBE2D1
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
UBE2S
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
CDC23
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
UBB
APC/C:Cdc20 mediated degradation of Cyclin B
BUB1B
Inactivation of APC/C via direct inhibition of the APC/C complex
BUB3
Inactivation of APC/C via direct inhibition of the APC/C complex
CDK1
Phosphorylation of the APC/C
CCNB1
Phosphorylation of the APC/C