TYMS — 카탈로그 54건
Gene TYMS
NCBI Gene 7298
국내 소싱 가능
54건
유전자 개요
TYMS가 암호화하는 티미딜산 합성효소(thymidylate synthase)는 10-메틸렌테트라하이드로폴레이트(methylene-THF)를 보조인자(cofactor)로 사용해 데옥시우리딜산(deoxyuridylate)을 데옥시티미딜산(deoxythymidylate)으로 전환하는 메틸화(methylation)를 촉매하며, 이를 통해 DNA 복제와 복구에 필수적인 dTMP(thymidine-5′-monophosphate) 풀을 유지한다. 이 효소는 5-플루오로유라실(5-fluorouracil)을 비롯한 약물의 주요 작용 부위로서 암 화학요법 약제의 표적으로 주목받아 왔다. TYMS의 다형성(polymorphism)은 유방암을 포함한 신생물(neoplasia)의 병인 및 화학요법 반응성과 관련될 수 있다.
G1/S-Specific TranscriptionInterconversion of nucleotide di- and triphosphates
dyskeratosis congenita, digenicbreast cancercolorectal cancerneoplasmdyskeratosis congenitanon-small cell lung carcinomabreast carcinomacolonic neoplasm
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Thymidylate synthase pharmacogenetics. · Invest New Drugs (2005)Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancer. · Gut Microbes (2023)Analysis and Experimental Validation of Rheumatoid Arthritis Innate Immunity Gene CYFIP2 and Pan-Cancer. · Front Immunol (2022)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cusabio | T094-110009-01 | CSB-RA584889A0HU | TYMS Recombinant Monoclonal Antibody | Rabbit | Monoclonal | Human | ELISA, WB | 50μl, 100μl | |
| MyBioSource | R247-128337-01 | MBS2028661 | Thymidylate Synthetase (TYMS), Polyclonal Antibody | Rabbit | Polyclonal | Human, Rat | WB; ICC; Immunohistochemistry (IHC) Formalin/Paraffin; ELISA | 0.1 mL | |
| Biosynth | F502-124360-01 | 70R-21082 | TYMS antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, IHC, IF, WB | 50 ul | |
| Biosynth | F502-102881-01 | 10R-1166 | TYMS antibody | Mouse | Monoclonal | Human; Cross: To be determined by end-user. | ELISA, IF, WB | 100 ul | |
| Biosynth | F502-125625-01 | 70R-2717 | TYMS antibody | Rabbit | Polyclonal | TYMS antibody was raised against the C terminal of TYMS; Cross: Human,Mouse,Rat | WB | 100 ul | |
| Cloud-Clone | T813-127062-01 | PAG963Hu01 | KO-Validated Polyclonal Antibody to Thymidylate Synthetase (TYMS) | Rabbit | Polyclonal | Human | WB; IHC | 100µl | |
| Cloud-Clone | T813-115298-01 | MAG963Hu21 | Monoclonal Antibody to Thymidylate Synthetase (TYMS) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| MyBioSource | R247-124728-01 | MBS200172 | TYMS, Monoclonal Antibody | Mouse | Monoclonal | Human | ELISA; WB; ICC; IF; FC/FACS | 0.05 mL | |
| MyBioSource | R247-151369-01 | MBS438481 | Thymidylate Synthase (TYMS), Monoclonal Antibody | Mouse | Monoclonal | Human | FC/FACS; IF; Immunohistochemistry (IHC) Formalin | 0.02 mg | |
| MyBioSource | R247-123136-01 | MBS1755340 | Thymidylate Synthase/TYMS, Polyclonal Antibody | Rabbit | Polyclonal | Human, Rat, Monkey | ELISA; IF; IHC; WB | 0.01 mg | |
| MyBioSource | R247-124203-01 | MBS190051 | Thymidylate Synthase (TYMS), Monoclonal Antibody | Mouse | Monoclonal | Human, Rat | ELISA; Immunoblot; Immunohistochemistry; Immunoprecipitation | 0.2 mg |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
CCNE1
G1/S-Specific Transcription
NME1
Interconversion of nucleotide di- and triphosphates
DUT
Interconversion of nucleotide di- and triphosphates
PCNA
G1/S-Specific Transcription
HDAC1
G1/S-Specific Transcription
DHFR
G1/S-Specific Transcription
AK7
Interconversion of nucleotide di- and triphosphates
CDK1
G1/S-Specific Transcription