TPMT — 카탈로그 18건
Gene TPMT
NCBI Gene 7172
국내 소싱 가능
18건
유전자 개요
티오퓨린 약물 대사에 관여하는 이 효소는 S-아데노실-L-메티오닌을 S-메틸 공여체로 사용하며 S-아데노실-L-호모시스테인을 부산물로 생성한다. 6-메르캅토퓨린과 같은 티오퓨린 약물은 항암 치료제로 쓰인다. 해당 효소 활성에 영향을 미치는 유전적 다형성은 개인별 민감도 및 독성 차이와 연관되어 티오퓨린 S-메틸전이효소(thioupurine S-methyltransferase) 결핍을 유발할 수 있다.
Azathioprine ADMEDefective TPMT causes TPMT deficiencyMethylation
thiopurine S-methyltransferase deficiencyagingneurodegenerative diseasetrait in response to mercaptopurinethiopurine methyltransferase activity measurementinborn errors of metabolismthiopurine metabolite measurementprotein measurement
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Clinical Pharmacogenetics Implementation Consortium Guideline for Thiopurine Dosing Based on TPMT and NUDT15 Genotypes: 2018 Update. · Clin Pharmacol Ther (2019)Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism. · DNA Cell Biol (1996)Implementation of TPMT testing. · Br J Clin Pharmacol (2014)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Biosynth | F502-112224-01 | 60R-1494 | TPMT antibody (biotin) | Rabbit | Polyclonal | Human; Cross: Human | ELISA, IHC, WB | 0.1 mg | |
| Biosynth | F502-112222-01 | 60R-1492 | TPMT antibody (HRP) | Rabbit | Polyclonal | Human; Cross: Human | ELISA, IHC, WB | 0.1 mg | |
| Biosynth | F502-112223-01 | 60R-1493 | TPMT antibody (FITC) | Rabbit | Polyclonal | Human; Cross: Human | ELISA, IHC, WB | 0.1 mg | |
| Biosynth | F502-124203-01 | 70R-20939 | TPMT antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, IHC, WB | 50 ul | |
| Biosynth | F502-105951-01 | 10R-6124 | TPMT antibody | Mouse | Monoclonal | Human; Cross: Human, Dog | FC, IHC, WB | 100 ul | |
| Biosynth | F502-105949-01 | 10R-6122 | TPMT antibody | Mouse | Monoclonal | Human; Cross: Human | IHC, WB | 100 ul | |
| Biosynth | F502-105950-01 | 10R-6123 | TPMT antibody | Mouse | Monoclonal | Human; Cross: Human | IF, IHC, WB | 100 ul | |
| Biosynth | F502-103827-01 | 10R-3130 | TPMT antibody | Mouse | Monoclonal | Human | ELISA, WB | 100 ul | |
| Biosynth | F502-105952-01 | 10R-6125 | TPMT antibody | Mouse | Monoclonal | Human; Cross: Human | IHC, WB | 100 ul | |
| Biosynth | F502-117999-01 | 70R-15216 | TPMT antibody | Rabbit | Polyclonal | Human; Cross: Human | ELISA, IHC, WB | 0.1 mg | |
| Cloud-Clone | T813-114197-01 | MAC821Hu22 | Monoclonal Antibody to Thiopurine Methyltransferase (TPMT) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-124281-01 | PAC821Hu01 | Polyclonal Antibody to Thiopurine Methyltransferase (TPMT) | Rabbit | Polyclonal | Human | WB; IHC | 100µl | |
| MyBioSource | R247-124793-01 | MBS200217 | TPMT, Monoclonal Antibody | Mouse | Monoclonal | Human | ELISA; WB; ICC; IF; FC/FACS | 0.05 mL |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.