STAT3가 암호화하는 단백질은 STAT 단백질 계열에 속하며, 사이토카인(cytokine)과 성장인자(growth factor)에 반응해 수용체 연관 키나아제(receptor-associated kinase)에 의해 인산화(phosphorylation)된 뒤 동종 또는 이종 이량체를 형성하여 세포핵으로 이동, 전사 활성인자(transcription activator)로 작용한다. 다양한 세포 자극에 반응하여 여러 유전자의 발현을 매개함으로써 세포 성장과 세포자멸사(apoptosis)를 비롯한 다수의 세포 과정에서 핵심적인 역할을 하며, 그 활성은 저분자 GTP가수분해효소(small GTPase)인 Rac1과의 결합으로 조절되고 PIAS3 단백질이 특이적 저해제로 작용한다. 또한 바이러스 및 세균 감염에 대한 숙주 반응 조절에 관여하며, 이 유전자의 돌연변이는 영아기 발병 다계통 자가면역질환 및 고면역글로불린 E 증후군(hyper-IgE syndrome)과 연관되어 있다.
Association of TriC/CCT with target proteins during biosynthesisBH3-only proteins associate with and inactivate anti-apoptotic BCL-2 membersCytoprotection by HMOX1Downstream signal transductionGrowth hormone receptor signalingInactivation of CSF3 (G-CSF) signalingInterleukin-10 signalingInterleukin-15 signalingInterleukin-20 family signalingInterleukin-21 signaling
autoimmune diseaseAutosomal dominant hyper-IgE syndromehyper-IgE recurrent infection syndrome 1, autosomal dominanthyper-IgE syndromehyper-IgE syndrome 6, autosomal dominant, with recurrent infectionscancerSTAT3 gain of functionCrohn's disease
Undiluted original Human body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Undiluted original Fish body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Mouse tissue homogenates, Cell lysates, cell culture supernates and other biological fluids
The minimum detectable dose of mouse STAT3 is typically less than 0.31ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration.
Rat tissue homogenates and other biological fluids
The minimum detectable dose of rat STAT3 is typically less than 0.054ng/mL. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined by adding two standard deviations to the mean optical density value of twenty zero standard replicates and calculating the corresponding concentration.
