SOST — 카탈로그 31건
Gene SOST
NCBI Gene 50964
국내 소싱 가능
31건
유전자 개요
스클레로스틴(Sclerostin)은 C-말단 시스테인 매듭형(CTCK) 도메인을 가진 분비형 당단백질로, 골형성단백질(BMP) 길항제인 DAN(differential screening-selected gene aberrative in neuroblastoma) 계열과 서열 유사성을 지닌다. 이 유전자의 기능 상실 돌연변이는 상염색체 열성 질환인 골경화증(sclerosteosis)과 연관되며, 이 질환은 진행성 골과형성(bone overgrowth)을 유발한다. 유전자 하류 영역의 결실로 인해 스클레로스틴 단백질의 발현이 감소하면, 반 부켐병(van Buchem disease)이라 불리는 보다 경증의 유사 질환과 연관된다.
Negative regulation of TCF-dependent signaling by WNT ligand antagonistsTCF dependent signaling in response to WNT
craniodiaphyseal dysplasiahyperostosis corticalis generalisataosteoporosispostmenopausal osteoporosislipid measurementcholesteryl ester measurementtotal cholesterol measurementhigh density lipoprotein cholesterol measurement
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) SOST/sclerostin, an osteocyte-derived negative regulator of bone formation. · Cytokine Growth Factor Rev (2005)A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population. · Am J Med Genet (2002)The role of osteoblasts in energy homeostasis. · Nat Rev Endocrinol (2019)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cloud-Clone | T813-124342-01 | PAC864Mu02 | Polyclonal Antibody to Sclerostin (SOST) | Rabbit | Polyclonal | Murine | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-124341-01 | PAC864Mu01 | Polyclonal Antibody to Sclerostin (SOST) | Rabbit | Polyclonal | Murine | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-114221-01 | MAC864Ra21 | Monoclonal Antibody to Sclerostin (SOST) | Mouse | Monoclonal | Rat | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-124340-01 | PAC864Hu01 | Polyclonal Antibody to Sclerostin (SOST) | Rabbit | Polyclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-124343-01 | PAC864Ra01 | Polyclonal Antibody to Sclerostin (SOST) | Rabbit | Polyclonal | Rat | WB | 100µl | |
| Cloud-Clone | T813-114220-01 | MAC864Hu22 | Monoclonal Antibody to Sclerostin (SOST) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| ELK Biotechnology | T376-120927-01 | ES6491 | Sclerostin rabbit pAb | Rabbit | Polyclonal | Human;Rat;Mouse; | WB;ELISA;IHC | 50μL | |
| Elabscience | T619-103414-01 | E-KAB-0465 | Human SOST Antibody Pair Set(E-KAB-0465) | Human | ELISA | 50μL&100μg |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
DKK1
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
WNT4
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
WIF1
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
DKK4
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
WNT3A
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
WNT5A
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
SFRP2
Negative regulation of TCF-dependent signaling by WNT ligand antagonists
SFRP1
Negative regulation of TCF-dependent signaling by WNT ligand antagonists