SMAD2 — 카탈로그 54건
Gene SMAD2
NCBI Gene 4087
국내 소싱 가능
54건
유전자 개요
SMAD2가 암호화하는 단백질은 초파리 Mad 및 예쁜꼬마선충(C. elegans) Sma 유전자 산물과 유사한 SMAD 단백질 계열에 속하며, 여러 신호전달 경로를 매개하는 신호전달자이자 전사(transcription) 조절자다. TGF(transforming growth factor)-베타 신호를 매개해 세포 증식, 세포자멸사(apoptosis), 분화 등 여러 세포 과정을 조절하는데, SARA 단백질과의 상호작용을 통해 TGF-베타 수용체(receptor)로 동원된 뒤 인산화(phosphorylation)되어 SARA에서 떨어져 나오고 SMAD4와 결합하며, 이 결합은 핵(nucleus) 내로의 이동에 중요해 표적 프로모터에 결합하여 다른 보조인자와 전사 억제 복합체를 형성한다. 또한 액티빈 1형 수용체 인산화효소(activin type 1 receptor kinase)에 의해서도 인산화되어 액티빈(activin) 신호를 매개한다.
Downregulation of SMAD2/3:SMAD4 transcriptional activityDownregulation of TGF-beta receptor signalingFOXO-mediated transcription of cell cycle genesFOXO-mediated transcription of oxidative stress, metabolic and neuronal genesFormation of axial mesodermFormation of definitive endodermGerm layer formation at gastrulationSMAD2/3 MH2 Domain Mutants in CancerSMAD2/3 Phosphorylation Motif Mutants in CancerSMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Loeys-Dietz syndrome 6congenital heart defects, multiple types, 8, with or without heterotaxycolorectal adenocarcinomaLoeys-Dietz syndromecancereosinophil countgenetic disorderprostate carcinoma
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) The Smad pathway. · Cytokine Growth Factor Rev (2000)Smad2 and Smad4 gene mutations in hepatocellular carcinoma. · Oncogene (1999)Creatine promotes cancer metastasis through activation of Smad2/3. · Cell Metab (2021)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cusabio | T094-107463-01 | CSB-PA15557A0Rb | SMAD2 Antibody | Rabbit | Polyclonal | Human, Mouse | ELISA, WB, IHC, IF | 50μg, 100μg | |
| Cusabio | T094-110039-01 | CSB-RA618017A250phHU | Phospho-SMAD2 (S250) Recombinant Monoclonal Antibody | Rabbit | Monoclonal | Human | ELISA, WB | 50μl, 100μl | |
| Cusabio | T094-110040-01 | CSB-RA618017A255phHU | Phospho-SMAD2 (S255) Recombinant Monoclonal Antibody | Rabbit | Monoclonal | Human | ELISA, IF | 50μl, 100μl | |
| Cloud-Clone | T813-109988-01 | LAC124Mu81 | FITC-Linked Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 2 (Smad2) | Rabbit | Antibody labeling | Murine | WB; IHC; ICC; IF. | 100µl | |
| Cusabio | T094-105250-01 | CSB-MA913719 | SMAD2 Monoclonal Antibody | Mouse | Monoclonal | Human | ELISA,WB,ICC | 100μl | |
| MyBioSource | R247-212497-01 | MBS9601998 | Smad2, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| MyBioSource | R247-212320-01 | MBS9601218 | Smad2, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| MyBioSource | R247-211224-01 | MBS9503908 | Smad2, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ELISA | 0.05 mL | |
| MyBioSource | R247-212321-01 | MBS9601219 | Smad2, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IF; ICC; ELISA | 0.1 mL | |
| MyBioSource | R247-211201-01 | MBS9503461 | Smad2, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ELISA | 0.05 mL | |
| MyBioSource | R247-210324-01 | MBS9456197 | SMAD2, Monoclonal Antibody | Rabbit | Monoclonal | Human | Most Applications | 0.1 mL | |
| Biosynth | F502-128935-01 | 70R-33675 | Smad2/3 antibody | Rabbit | Polyclonal | Smad2/3 antibody detects endogenous levels of total Smad2/3 protein; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Biosynth | F502-128923-01 | 70R-33664 | Smad2 antibody | Rabbit | Polyclonal | Smad2 antibody detects endogenous levels of total Smad2 protein; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Biosynth | F502-132292-01 | 70R-37370 | Smad2 antibody (Thr220) | Rabbit | Polyclonal | Human; Cross: Mouse, Rat | WB | 0.1 mg | |
| Biosynth | F502-132290-01 | 70R-37369 | Smad2 antibody (Ser467) | Rabbit | Polyclonal | Human; Cross: Mouse, Rat | WB | 0.1 mg | |
| Biosynth | F502-134433-01 | 70R-50026 | SMAD2/3 antibody | Rabbit | Polyclonal | Recognizes endogenous levels of SMAD2/3 protein; Cross: Rat, Bovine, Cat | WB, IHC | 100 ul | |
| Biosynth | F502-128921-01 | 70R-33662 | Smad2 antibody (Ser250) | Rabbit | Polyclonal | Smad2 antibody detects endogenous levels of Smad2 only when phosphorylated at serine 250; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Biosynth | F502-128922-01 | 70R-33663 | Smad2 antibody | Rabbit | Polyclonal | Smad2 antibody detects endogenous levels of total Smad2 protein; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Biosynth | F502-128928-01 | 70R-33669 | Smad2 antibody | Rabbit | Polyclonal | Smad2 antibody detects endogenous levels of total Smad2 protein; Cross: Mouse, Rat | WB, IHC, IF, ELISA | 0.1 mg | |
| Biosynth | F502-128927-01 | 70R-33668 | Smad2 antibody (Thr220) | Rabbit | Polyclonal | Smad2 antibody detects endogenous levels of Smad2 only when phosphorylated at threonine 220; Cross: Mouse, Rat | IF, ELISA | 0.1 mg | |
| Biosynth | F502-105731-01 | 10R-5831 | SMAD2 antibody | Mouse | Monoclonal | Human; Cross: Human | IF, WB | 100 ul | |
| Biosynth | F502-123593-01 | 70R-20382 | SMAD2 antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, IHC, WB | 50 ul | |
| Biosynth | F502-126028-01 | 70R-30614 | SMAD2 antibody (Ser467) | Rabbit | Polyclonal | SMAD2 antibody detects endogenous levels of Smad2 only when phosphorylated at serine 467; Cross: Mouse, Rat | WB, IHC, IF, ELISA | 0.1 mg | |
| Biosynth | F502-128920-01 | 70R-33661 | Smad2 antibody | Rabbit | Polyclonal | Smad2 antibody detects endogenous levels of total Smad2 protein; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Biosynth | F502-134432-01 | 70R-50025 | SMAD2 antibody | Rabbit | Polyclonal | Recognizes endogenous levels of SMAD2 protein; Cross: Mouse, Rat, Bovine, Chicken | WB, IHC, IF, ICC | 100 ul | |
| Biosynth | F502-126027-01 | 70R-30613 | SMAD2 antibody (Ser467) | Rabbit | Polyclonal | SMAD2 antibody detects endogenous levels of Smad2 only when phosphorylated at serine 467; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-105732-01 | 10R-5832 | SMAD2 antibody | Mouse | Monoclonal | Human; Cross: Human | FC, IF, WB | 100 ul | |
| Biosynth | F502-128934-01 | 70R-33674 | Smad2/3 antibody (Thr8) | Rabbit | Polyclonal | Smad2/3 antibody detects endogenous levels of Smad2/3 only when phosphorylated at threonine 8; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Cloud-Clone | T813-123175-01 | PAC124Hu01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 2 (Smad2) | Rabbit | Polyclonal | Human | WB | 100µl | |
| Cloud-Clone | T813-123176-01 | PAC124Mu01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 2 (Smad2) | Rabbit | Polyclonal | Murine | IHC | 100µl | |
| Cloud-Clone | T813-123178-01 | PAC124Ra01 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 2 (Smad2) | Rabbit | Polyclonal | Rat | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-123177-01 | PAC124Mu02 | Polyclonal Antibody to Mothers Against Decapentaplegic Homolog 2 (Smad2) | Rabbit | Polyclonal | Murine | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-113827-01 | MAC124Hu21 | Monoclonal Antibody to Mothers Against Decapentaplegic Homolog 2 (Smad2) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Biosynth | F502-108953-01 | 20R-2140 | SMAD2 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | WB | 0.05 mg | ||
| Biosynth | F502-108952-01 | 20R-2139 | SMAD2 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | WB | 0.05 mg | ||
| Biosynth | F502-109272-01 | 20R-2468 | SMAD2 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IF, WB | 0.05 mg | ||
| Biosynth | F502-109273-01 | 20R-2469 | SMAD2 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IHC, WB | 0.05 mg | ||
| MyBioSource | R247-154358-01 | MBS475095 | Smad2, Monoclonal Antibody | Mouse | Monoclonal | Human | WB; ICC | 0.1 mL | |
| MyBioSource | R247-191133-01 | MBS8242203 | SMAD2, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Bovine, Monkey, Pig, Sheep, Chicken, Zebrafish | WB; IHC; IF; ICC | 0.03 mL | |
| MyBioSource | R247-113765-01 | MBS128337 | SMAD2-S467, Antibody | Rabbit | Human, Mouse, Rat | WB | 0.02 mL | ||
| MyBioSource | R247-160424-01 | MBS613106 | Smad2, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB | ||
| Biosynth | F502-136379-01 | 70R-51804 | SMAD2/3 antibody | Rabbit | Polyclonal | Recognizes endogenous levels of SMAD2/3 protein; Cross: Mouse, Rat, Bovine, Chicken | WB | 100 ul | |
| ELK Biotechnology | T376-116994-01 | ES1458 | Smad2 (phospho Ser467) rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;IHC;IF;ELISA | 50μL | |
| ELK Biotechnology | T376-120813-01 | ES6154 | Smad2 (phospho Ser250) rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;ELISA;IHC | 50μL |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
SMAD3
SMAD2/3 MH2 Domain Mutants in Cancer
SMAD4
SMAD2/3 MH2 Domain Mutants in Cancer
TGFB1
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR2
SMAD2/3 Phosphorylation Motif Mutants in Cancer
TGFBR1
SMAD2/3 Phosphorylation Motif Mutants in Cancer
CTNNB1
Formation of axial mesoderm
MAPK1
Signaling by Activin
MAPK3
Signaling by Activin