SERPINE1 — 카탈로그 46건
Gene SERPINE1
NCBI Gene 5054
취급 제조사 4곳
국내 소싱 가능
46건
유전자 개요
SERPINE1은 세린 단백질분해효소 저해제(serine proteinase inhibitor, serpin) 슈퍼패밀리(superfamily)에 속하는 단백질을 암호화하며, 조직 플라스미노겐 활성화인자(tissue plasminogen activator, tPA)와 유로키나아제(urokinase, uPA)를 억제하는 주된 저해제로서 섬유소용해(fibrinolysis)를 막는다. 또한 선천 항바이러스 면역의 한 구성 요소로 기능한다. 이 유전자의 결함은 플라스미노겐 활성화인자 저해제-1 결핍(PAI-1 deficiency)을 일으키며, 산물의 고농도는 혈전성향증(thrombophilia)과 연관된다.
BMAL1:CLOCK,NPAS2 activates circadian expressionDissolution of Fibrin ClotDownregulation of SMAD2/3:SMAD4 transcriptional activityECM proteoglycansPlatelet degranulation Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transitionSARS-CoV-1 targets host intracellular signalling and regulatory pathwaysSMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
congenital plasminogen activator inhibitor type 1 deficiencyplasminogen activator inhibitor 1 measurementvenous thromboembolismcoronary artery diseaseIschemic strokecirculating fibrinogen levelsAbnormal bleedinghemorrhage
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) A Narrative Review on Plasminogen Activator Inhibitor-1 and Its (Patho)Physiological Role: To Target or Not to Target? · Int J Mol Sci (2021)uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy. · Oncotarget (2016)Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation. · Mol Cancer (2024)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
SMAD3
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SMAD4
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
ITGA2
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
EP300
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
SP1
SARS-CoV-1 targets host intracellular signalling and regulatory pathways
CDH1
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
SOX2
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition
ZEB1
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition