RXRA — 카탈로그 19건
Gene RXRA
NCBI Gene 6256
취급 제조사 4곳
국내 소싱 가능
19건
유전자 개요
레티노이드 X 수용체(RXR)와 레티노산 수용체(RAR)는 핵 수용체(nuclear receptor)로, 레티노산 매개 유전자 활성화에 관여함으로써 레티노이드(retinoid)의 생물학적 효과를 매개한다. 이 수용체들은 표적 유전자의 프로모터(promoter) 내 특이적 서열에 동종이량체(homodimer) 또는 이종이량체(heterodimer)로 결합하여 전사인자(transcription factor)로 기능한다. RXRA 유전자가 인코딩하는 단백질은 스테로이드 및 갑상선 호르몬 수용체 초유전자족(steroid and thyroid hormone receptor superfamily)에 속하는 전사 조절인자이며, 이 유전자의 선택적 스플라이싱(alternative splicing)에 의해 다수의 전사체 변이체(transcript variant)가 생성된다.
Activation of anterior HOX genes in hindbrain development during early embryogenesisActivation of gene expression by SREBF (SREBP)BMAL1:CLOCK,NPAS2 activates circadian expressionCarnitine shuttleCytoprotection by HMOX1Endogenous sterolsExpression of BMAL (ARNTL), CLOCK, and NPAS2Heme signalingMLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosisNR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
psoriasissex hormone-binding globulin measurementEczematoid dermatitisCutaneous T-cell lymphomaurinary bladder cancertestosterone measurementneoplasmhemoglobin measurement
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability. · Mol Cell (2023)Evolutionary history of sickle-cell mutation: implications for global genetic medicine. · Hum Mol Genet (2021)RXRA gene variations influence Alzheimer's disease risk and cholesterol metabolism. · J Cell Mol Med (2009)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Biosynth | F502-122324-01 | 70R-1922 | RXRA antibody | Rabbit | Polyclonal | RXRA antibody was raised against the N terminal of RXRA; Cross: Human | WB | 100 ul | |
| Biosynth | F502-123232-01 | 70R-20052 | RXRA antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, WB | 50 ul | |
| Biosynth | F502-122500-01 | 70R-1938 | RXRA antibody | Rabbit | Polyclonal | RXRA antibody was raised against the N terminal of RXRA; Cross: Human | WB | 100 ul | |
| Biosynth | F502-122335-01 | 70R-1923 | RXRA antibody | Rabbit | Polyclonal | RXRA antibody was raised against the C terminal of RXRA; Cross: Human,Mouse,Rat | WB | 100 ul | |
| Cloud-Clone | T813-122986-01 | PAC043Hu01 | Polyclonal Antibody to Retinoid X Receptor Alpha (RXRa) | Rabbit | Polyclonal | Human | Testing in progress | 100µl | |
| Cloud-Clone | T813-113755-01 | MAC043Hu21 | Monoclonal Antibody to Retinoid X Receptor Alpha (RXRa) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-122987-01 | PAC043Mu01 | Polyclonal Antibody to Retinoid X Receptor Alpha (RXRa) | Rabbit | Polyclonal | Murine | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-122988-01 | PAC043Mu02 | Polyclonal Antibody to Retinoid X Receptor Alpha (RXRa) | Rabbit | Polyclonal | Murine | WB; IHC; ICC; IP. | 100µl | |
| MyBioSource | R247-146588-01 | MBS3201842 | RXRA, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Dog, Guinea Pig, Pig, Horse | WB | 0.1 mL | |
| MyBioSource | R247-150042-01 | MBS420574 | RXR alpha (RXRA), Polyclonal Antibody | Goat | Polyclonal | Human, Mouse, Rat | EIA; WB | 0.1 mg |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
NCOR1
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
PPARA
Regulation of lipid metabolism by PPARalpha
MED1
Regulation of lipid metabolism by PPARalpha
CREBBP
Regulation of lipid metabolism by PPARalpha
NCOR2
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
CYP7B1
Synthesis of bile acids and bile salts
CYP7A1
Synthesis of bile acids and bile salts
PCK1
NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis