RUNX1 — 카탈로그 72건
Gene RUNX1
NCBI Gene 861
국내 소싱 가능
72건
유전자 개요
RUNX1이 암호화하는 단백질은 핵심결합인자(core binding factor, CBF)의 알파 소단위체로, CBF는 여러 인핸서와 프로모터의 핵심 요소에 결합하는 이종이량체 전사인자(heterodimeric transcription factor)이다. 이 단백질은 정상 조혈(hematopoiesis) 발달에 관여하는 것으로 여겨지며, RUNX1을 포함하는 염색체 전좌(chromosomal translocation)는 잘 보고되어 있고 여러 유형의 백혈병(leukemia)과 연관되어 있다. 또한 서로 다른 아이소폼(isoform)을 암호화하는 세 가지 전사체 변이가 확인되었다.
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)Estrogen-dependent gene expressionPre-NOTCH Transcription and TranslationRUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownRUNX1 regulates estrogen receptor mediated transcriptionRUNX1 regulates expression of components of tight junctionsRUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionRUNX1 regulates transcription of genes involved in BCR signalingRUNX1 regulates transcription of genes involved in WNT signaling
hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1acute myeloid leukemiahereditary thrombocytopenia and hematologic cancer predisposition syndromeThrombocytopeniaplatelet countplatelet criteosinophil countasthma
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Role of RUNX1 in hematological malignancies. · Blood (2017)RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis. · Front Biosci (Landmark Ed) (2012)An update on the molecular pathogenesis and potential therapeutic targeting of AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1. · Blood Adv (2020)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
RUNX2
RUNX2 regulates genes involved in differentiation of myeloid cells
LGALS3
RUNX2 regulates genes involved in differentiation of myeloid cells
ESR1
RUNX1 regulates estrogen receptor mediated transcription
AXIN1
RUNX1 regulates estrogen receptor mediated transcription
FOXP3
RUNX1 regulates transcription of genes involved in WNT signaling
IL3
RUNX1 regulates transcription of genes involved in interleukin signaling
OCLN
RUNX1 regulates expression of components of tight junctions
LIFR
RUNX1 regulates transcription of genes involved in interleukin signaling