RORA — 카탈로그 31건
Gene RORA
NCBI Gene 6095
취급 제조사 4곳
국내 소싱 가능
31건
유전자 개요
이 유전자는 핵 호르몬 수용체(nuclear hormone receptor)의 NR1 아형 단백질을 암호화한다. 해당 단백질은 단량체(monomer) 또는 상동 이량체(homodimer)로서 여러 유전자 상위의 호르몬 반응 요소(hormone response element)에 결합하여 해당 유전자의 발현을 강화한다. 암호화된 단백질은 기관 발생 및 분화에 관여하는 뉴클레오사이드 이인산 키나아제(nucleoside diphosphate kinase)인 NM23-2 및 종양 전이 억제 후보 유전자(tumor metastasis suppressor candidate gene)의 산물인 NM23-1과 상호작용하는 것으로 밝혀졌다. 또한, 생체 시계 리듬(circadian rhythm)에 관여하는 일부 유전자의 전사 조절을 돕는 것으로 나타났다. 본 유전자에 대해 서로 다른 아이소폼(isoform)을 암호화하는 네 가지 전사 변이체(transcript variant)가 기술되어 있다.
Expression of BMAL (ARNTL), CLOCK, and NPAS2Heme signalingInterleukin-4 and Interleukin-13 signalingNuclear Receptor transcription pathwayPPARA activates gene expressionPhosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genesPhosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promotersRORA,B,C and NR1D1 (REV-ERBA) regulate gene expressionSUMOylation of intracellular receptorsThe CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
intellectual developmental disorder with or without epilepsy or cerebellar ataxiabody heightbody composition measurementlean body massbody weightsitting height measurementIntellectual disabilitypulse pressure measurement
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Bioinformatics and Network Pharmacology Identify the Therapeutic Role and Potential Mechanism of Melatonin in AD and Rosacea. · Front Immunol (2021)The retinoid-related orphan receptor alpha (RORA) gene and fear-related psychopathology. · J Affect Disord (2013)The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression. · Cancer Res (2024)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| MyBioSource | R247-175285-01 | MBS7103474 | RORA, Polyclonal Antibody | Rabbit | Polyclonal | Human | ELISA | 0.05 mg | |
| MyBioSource | R247-161497-01 | MBS6154708 | ROR alpha (RORA), Monoclonal Antibody | Mouse | Monoclonal | Human | ELISA | 0.1 mL | |
| MyBioSource | R247-175283-01 | MBS7103472 | RORA, Polyclonal Antibody | Rabbit | Polyclonal | Human | ELISA | 0.05 mg | |
| MyBioSource | R247-175282-01 | MBS7103471 | RORA, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | ELISA; WB | 0.05 mg | |
| MyBioSource | R247-161254-01 | MBS6149405 | ROR alpha (RORA), Monoclonal Antibody | Mouse | Monoclonal | Human | ELISA | 0.1 mL | |
| MyBioSource | R247-175284-01 | MBS7103473 | RORA, Polyclonal Antibody | Rabbit | Polyclonal | Human | ELISA | 0.05 mg | |
| MyBioSource | R247-162956-01 | MBS6192360 | ROR alpha (RORA), Monoclonal Antibody | Mouse | Monoclonal | Human | FLISA | 0.1 mL | |
| Biosynth | F502-122511-01 | 70R-1939 | RORA antibody | Rabbit | Polyclonal | RORA antibody was raised against the middle region of RORA; Cross: Human,Dog | WB | 100 ul | |
| Biosynth | F502-122313-01 | 70R-1921 | RORA antibody | Rabbit | Polyclonal | RORA antibody was raised against the N terminal of RORA; Cross: Human | WB | 100 ul | |
| Biosynth | F502-122489-01 | 70R-1937 | RORA antibody | Rabbit | Polyclonal | RORA antibody was raised against the N terminal of RORA; Cross: Human,Mouse,Rat | WB | 100 ul | |
| Biosynth | F502-114943-01 | 70R-1006 | RORA antibody | Rabbit | Polyclonal | RORA antibody was raised against the middle region of RORA; Cross: Human, Mouse, Rat, Dog, ZebraFish | WB, IHC | 100 ul | |
| Biosynth | F502-114889-01 | 70R-1001 | RORA antibody | Rabbit | Polyclonal | RORA antibody was raised against the N terminal of RORA; Cross: Human,Mouse,Rat,Dog | WB | 100 ul | |
| Biosynth | F502-127200-01 | 70R-31692 | RORA antibody | Rabbit | Polyclonal | RORA antibody detects endogenous levels of total RORA protein | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-123114-01 | 70R-19944 | RORA antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, WB | 50 ul | |
| Cloud-Clone | T813-125558-01 | PAD947Hu01 | KO-Validated Polyclonal Antibody to RAR Related Orphan Receptor Alpha (RORa) | Rabbit | Polyclonal | Human | WB | 100µl | |
| MyBioSource | R247-170817-01 | MBS669267 | ROR alpha (RORA), Polyclonal Antibody | Rabbit | Polyclonal | Human | WB | 0.025 mg | |
| MyBioSource | R247-147014-01 | MBS3207815 | RORA, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Pig, Goat, Horse | WB; IHC | 0.1 mL | |
| MyBioSource | R247-192083-01 | MBS8304271 | ROR alpha (RORA), Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | WB; IF; ICC | 0.03 mL | |
| MyBioSource | R247-147018-01 | MBS3207847 | Rora, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB | 0.1 mL | |
| MyBioSource | R247-198573-01 | MBS9125881 | RORA, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | WB; IHC; IF | 0.02 mL | |
| MyBioSource | R247-124717-01 | MBS2001648 | RAR Related Orphan Receptor Alpha (RORa), Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | ICC; Immunohistochemistry (IHC) - Formalin/Paraffin; ELISA; WB | 0.1 mL |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
CREBBP
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
CLOCK
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
PER3
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
PER2
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
PER1
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
CRY1
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
PPARA
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
RXRA
RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression