RAN — 카탈로그 70건
Gene RAN
NCBI Gene 5901
취급 제조사 4곳
국내 소싱 가능
70건
유전자 개요
RAN(ras-related nuclear protein)은 RAS 슈퍼패밀리(superfamily)에 속하는 소형 GTP 결합 단백질로, 핵공 복합체(nuclear pore complex)를 통한 RNA와 단백질의 이동에 필수적이며 DNA 합성과 세포 주기(cell cycle) 진행 조절에도 관여한다. RAN의 핵 내 국재화에는 RCC1(regulator of chromosome condensation 1)이 필요하고 RAN의 돌연변이는 DNA 합성을 저해하며, 거대분자의 핵-세포질 교환과는 별개로 미세소관(microtubule) 네트워크의 형성과 조직화를 조절해 유사분열(mitosis) 시 미세소관 중합을 제어하는 핵심 신호 분자일 수 있다. 또한 RAN은 안드로겐 수용체(androgen receptor, AR)의 공동활성화 인자로 작용하는데, AR 내 폴리글루타민(polyglutamine) 확장이 일어나면 공동활성화가 약해져 케네디병(Kennedy’s disease) 진행 과정에서 부분적 안드로겐 불감성으로 이어질 수 있다.
MicroRNA (miRNA) biogenesisNEP/NS2 Interacts with the Cellular Export MachineryNuclear import of Rev proteinPostmitotic nuclear pore complex (NPC) reformationRegulation of cholesterol biosynthesis by SREBP (SREBF)Rev-mediated nuclear export of HIV RNATranscriptional regulation by small RNAstRNA processing in the nucleus
HIV infectioninfluenzaneurodegenerative diseaseFEV/FVC ratiopemphigus foliaceuscolorectal carcinomacancerneoplasm
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) RAN Translation in Huntington Disease. · Neuron (2015)Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice. · Proc Natl Acad Sci U S A (2020)The Ran-GTPase and cell-cycle control. · Bioessays (2001)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cusabio | T094-109757-01 | CSB-RA191819A0HU | RAN Recombinant Monoclonal Antibody | Rabbit | Monoclonal | Human | ELISA, IHC, IF, FC | 50μl, 100μl | |
| Abbexa | F158-100093-01 | abx000929 | GTP-Binding Nuclear Protein RAN (RAN) Antibody | Rabbit | Polyclonal | Mouse, Rat | ELISA, WB, IF/ICC | 20 µl | |
| Abbexa | F158-119612-01 | abx431547 | Guanosine Triphosphatase Ran (RAN) Antibody | Goat | Polyclonal | Human, Mouse | P-ELISA, WB, IHC | 200 µl | |
| Abbexa | F158-114796-01 | abx321684 | GTP-Binding Nuclear Protein RAN (RAN) Antibody | Rabbit | Polyclonal | Human | ELISA, WB, IHC | 20 µl | |
| Abbexa | F158-105081-01 | abx119043 | GTP-Binding Nuclear Protein RAN (RAN) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA, WB, IHC | 10 µg | |
| Abbexa | F158-111152-01 | abx237100 | Guanosine Triphosphatase Ran (RAN) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA, WB, IHC, IF/ICC, IP | 100 µg | |
| Abbexa | F158-101860-01 | abx032938 | GTP-Binding Nuclear Protein RAN (RAN) Antibody | Rabbit | Polyclonal | Human, Mouse | ELISA, WB, IHC, FCM | 80 µl | |
| Abbexa | F158-102249-01 | abx038363 | Guanosine Triphosphatase Ran (RAN) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Chicken, Dog, Frog | ELISA, WB | 100 µg | |
| MyBioSource | R247-213484-01 | MBS9606818 | RAN, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| Biosynth | F502-126156-01 | 70R-30732 | RAN antibody | Rabbit | Polyclonal | RAN antibody detects endogenous levels of total RAN protein; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Biosynth | F502-134739-01 | 70R-50306 | RAN antibody | Rabbit | Polyclonal | Recognizes endogenous levels of RAN protein; Cross: Mouse, Rat, Bovine, Dog, Monkey | WB, IHC | 100 ul | |
| Biosynth | F502-122914-01 | 70R-19760 | RAN antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, IHC, WB | 50 ul | |
| MyBioSource | R247-208333-01 | MBS9411274 | RAN, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF | 0.05 mL | |
| MyBioSource | R247-201575-01 | MBS9210295 | RAN, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Bovine, Monkey, Chicken, Zebrafish | WB; ELISA; IHC-p; FC | 0.08 mL | |
| MyBioSource | R247-147316-01 | MBS3212948 | RAN, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Dog, Pig, Sheep, Zebrafish, Horse | WB | 0.1 mL | |
| MyBioSource | R247-122487-01 | MBS1750350 | Ran, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | IHC; WB | 0.01 mg | |
| MyBioSource | R247-136694-01 | MBS2517142 | RAN, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; IP; RIP | ||
| Biosynth | F502-136747-01 | 70R-5529 | Ran antibody | Rabbit | Polyclonal | Ran antibody was raised against the middle region of RAN; Cross: Human,Mouse,Rat,Dog,C.elegans,Drosophila | WB | 100 ul |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
NUP133
Postmitotic nuclear pore complex (NPC) reformation
NUP62
Postmitotic nuclear pore complex (NPC) reformation
NUP98
Postmitotic nuclear pore complex (NPC) reformation
KPNB1
Regulation of cholesterol biosynthesis by SREBP (SREBF)
TPR
NEP/NS2 Interacts with the Cellular Export Machinery
NUP153
NEP/NS2 Interacts with the Cellular Export Machinery
NUP50
NEP/NS2 Interacts with the Cellular Export Machinery
SEC23A
Regulation of cholesterol biosynthesis by SREBP (SREBF)