PROC — 카탈로그 26건
Gene PROC
NCBI Gene 5624
국내 소싱 가능
26건
유전자 개요
이 유전자는 비타민 K 의존성 혈장 당단백질(glycoprotein)을 암호화한다. 이 단백질은 트롬빈-트롬보모듈린 복합체에 의해 활성 형태로 절단된다. 이 활성 형태는 세린 단백질분해효소(serine protease) 도메인을 포함하며, 활성화된 응고 인자 V 및 VIII의 분해에 관여한다. 이 유전자의 돌연변이는 단백질 C 결핍으로 인한 혈전증(thrombophilia), 신생아 괴사성 자반증, 재발성 정맥 혈전증과 관련이 있다.
Cell surface interactions at the vascular wallCommon Pathway of Fibrin Clot FormationGamma-carboxylation of protein precursorsIntrinsic Pathway of Fibrin Clot FormationPost-translational protein phosphorylationRegulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)Removal of aminoterminal propeptides from gamma-carboxylated proteinsTransport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
hereditary thrombophilia due to congenital protein C deficiencydeep vein thrombosisprotein c deficiencyvenous thromboembolismPhlebitisThrombophlebitisAbnormal thrombosisPortal vein thrombosis
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) DNA strand bias in the repair of the p53 gene in normal human and xeroderma pigmentosum group C fibroblasts. · Cancer Res (1993)Identification of an intronic regulatory element in the human protein C (PROC) gene. · Hum Genet (2000)Polymorphic variation in the human protein C (PROC) gene promoter can influence transcriptional efficiency in vitro. · Blood Coagul Fibrinolysis (1995)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
PROS1
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
F2
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
F10
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
F9
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
F7
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
GAS6
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
PROZ
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
BGLAP
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus