POLR3A — 카탈로그 19건
Gene POLR3A
NCBI Gene 11128
취급 제조사 3곳
국내 소싱 가능
19건
유전자 개요
이 유전자 산물은 RNA polymerase III의 촉매 복합체로, 작은 RNA를 합성한다. 또한, 이 단백질은 외부 DNA를 감지하여 선천 면역 반응을 유발하는 센서 역할을 한다.
Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Abortive And Retractive InitiationRNA Polymerase III Chain ElongationRNA Polymerase III Transcription Initiation From Type 1 PromoterRNA Polymerase III Transcription Initiation From Type 2 PromoterRNA Polymerase III Transcription Initiation From Type 3 PromoterRNA Polymerase III Transcription Termination
Leukoencephalopathy - ataxia - hypodontia - hypomyelinationWiedemann-Rautenstrauch syndromeHypomyelination - hypogonadotropic hypogonadism - hypodontialeukodystrophy, hypomyelinating, 7, with or without oligodontia and/or hypogonadotropic hypogonadismPOLR3A-related disorderleukodystrophyPOLR-related leukodystrophygenetic disorder
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Clinical spectrum of 4H leukodystrophy caused by POLR3A and POLR3B mutations. · Neurology (2014)RNA polymerase III is required for the repair of DNA double-strand breaks by homologous recombination. · Cell (2021)Hypomorphic mutations in POLR3A are a frequent cause of sporadic and recessive spastic ataxia. · Brain (2017)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
TBP
RNA Polymerase III Transcription Initiation From Type 2 Promoter
SSB
RNA Polymerase III Transcription Termination
NFIB
RNA Polymerase III Transcription Termination
ZNF143
RNA Polymerase III Transcription Initiation From Type 3 Promoter
AIM2
Cytosolic sensors of pathogen-associated DNA XRCC6
Cytosolic sensors of pathogen-associated DNA XRCC5
Cytosolic sensors of pathogen-associated DNA PRKDC
Cytosolic sensors of pathogen-associated DNA