PLK1 — 카탈로그 18건
Gene PLK1
NCBI Gene 5347
취급 제조사 3곳
국내 소싱 가능
18건
유전자 개요
이 단백질 키나아제(kinase)는 세린/트레오닌 인산화를 촉매한다. 유사분열(mitosis) 동안 높은 수준으로 발현되며, 다양한 종류의 암(cancer)에서 그 수치가 증가한다. 이 단백질의 감소는 암세포의 증식을 억제하고 세포자멸사(apoptosis)를 유도하여 암 치료의 표적이 된다.
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1AURKA Activation by TPX2Activation of NIMA Kinases NEK9, NEK6, NEK7Amplification of signal from unattached kinetochores via a MAD2 inhibitory signalAnchoring of the basal body to the plasma membraneCondensation of Prophase ChromosomesCyclin A/B1/B2 associated events during G2/M transitionEML4 and NUDC in mitotic spindle formationGolgi Cisternae Pericentriolar Stack ReorganizationLoss of Nlp from mitotic centrosomes
neurodegenerative diseaseAlzheimer diseaseParkinson diseaselysosomal storage diseasemultiple sclerosiserythrocyte volumeMicrocephalyIntellectual disability
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Polo-like kinases and oncogenesis. · Oncogene (2005)Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells. · Cell Rep (2015)Non-mitotic functions of polo-like kinases in cancer cells. · Biochim Biophys Acta Rev Cancer (2021)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| MyBioSource | R247-212207-01 | MBS9600713 | PLK1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC | 0.1 mL | |
| Biosynth | F502-128324-01 | 70R-32724 | PLK1 antibody (Ser137) | Rabbit | Polyclonal | PLK1 antibody detects endogenous levels of PLK1 only when phosphorylated at serine 137; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Biosynth | F502-105354-01 | 10R-5317 | PLK1 antibody | Mouse | Monoclonal | Human; Cross: Human | IHC, WB | 100 ul | |
| Biosynth | F502-131391-01 | 70R-36347 | PLK1 antibody | Rabbit | Polyclonal | PLK1 antibody detects endogenous levels of total PLK1 protein; Cross: Mouse | WB, IF, ELISA | 0.1 mg | |
| Biosynth | F502-130725-01 | 70R-35548 | PLK1 antibody (Thr210) | Rabbit | Polyclonal | Human, Mouse, Rat; Cross: Mouse, Rat. Specific detection of phosphorylated Human: Thr210, Mouse: Thr210, Rat: Thr210 | IHC, ELISA | 0.1 mg | |
| Biosynth | F502-105353-01 | 10R-5316 | PLK1 antibody | Mouse | Monoclonal | Human; Cross: Human, Monkey, Dog | WB | 100 ul | |
| Biosynth | F502-105357-01 | 10R-5321 | PLK1 antibody | Mouse | Monoclonal | Human; Cross: Human, Dog | IHC, WB | 100 ul | |
| Biosynth | F502-105355-01 | 10R-5318 | PLK1 antibody | Mouse | Monoclonal | Human; Cross: Human | IHC, WB | 100 ul | |
| Biosynth | F502-105356-01 | 10R-5320 | PLK1 antibody | Mouse | Monoclonal | Human; Cross: Human | IHC, WB | 100 ul | |
| MyBioSource | R247-147035-01 | MBS3208065 | PLK1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Pig, Horse | IHC; WB | 0.1 mL | |
| MyBioSource | R247-151053-01 | MBS4381038 | PLK1 (Marker of Mitosis), Monoclonal Antibody | Mouse | Monoclonal | Human, Mouse | ELISA; WB | 0.02 mg | |
| Biosynth | F502-136781-01 | 70R-5563 | PLK1 antibody | Rabbit | Polyclonal | Human,Mouse | WB | 100 ul | |
| Biosynth | F502-136167-01 | 70R-51610 | PLK1 antibody | Rabbit | Polyclonal | Recognizes endogenous levels of PLK1 protein; Cross: Bovine, Monkey, Pig | WB, IHC | 100 ul | |
| ELK Biotechnology | T376-120974-01 | ES6620 | Plk rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;IHC;IF;ELISA | 50μL | |
| Biosynth | F502-117824-01 | 70R-15045 | PLK1 antibody (Thr210) | Rabbit | Polyclonal | WB | 100 ul | ||
| Biosynth | F502-117825-01 | 70R-15046 | PLK1 antibody (Ser482,486,490) | Rabbit | Polyclonal | WB | 100 ul |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
CCNB1
Phosphorylation of Emi1
CDK1
Phosphorylation of Emi1
KIF20A
Mitotic Telophase/Cytokinesis
NEK7
Activation of NIMA Kinases NEK9, NEK6, NEK7
MAPRE1
The role of GTSE1 in G2/M progression after G2 checkpoint
HSP90AA1
The role of GTSE1 in G2/M progression after G2 checkpoint
FOXM1
Polo-like kinase mediated events
CDC25A
Polo-like kinase mediated events