PLCG2 — 카탈로그 18건
Gene PLCG2
NCBI Gene 5336
취급 제조사 3곳
국내 소싱 가능
18건
유전자 개요
PLCG2 유전자가 지정하는 단백질은 막을 관통하는 신호 전달 효소로, 칼슘을 보조 인자로 사용하여 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate를 1D-myo-inositol 1,4,5-trisphosphate (IP3)와 diacylglycerol (DAG)으로 전환시키는 반응을 촉매합니다. IP3와 DAG는 세포막을 가로질러 성장인자 수용체 및 면역계 수용체로부터 신호를 전달하는 데 중요한 두 번째 메신저 분자입니다. 이 유전자의 돌연변이는 자가염증, 항체 결핍, 면역 조절 이상 증후군 및 가족성 한랭 자가염증 증후군 3에서 발견되었습니다.
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersCLEC7A (Dectin-1) signalingDAP12 signalingDectin-2 familyErythropoietin activates Phospholipase C gamma (PLCG)FCERI mediated Ca+2 mobilizationFCERI mediated MAPK activationFCGR3A-mediated IL10 synthesisGPVI-mediated activation cascadeGeneration of second messenger molecules
PLCG2-associated antibody deficiency and immune dysregulationautoinflammation-PLCG2-associated antibody deficiency-immune dysregulationfamilial cold autoinflammatory syndrome 3Alzheimer diseaseplatelet volumecutaneous Leishmaniasisleukocyte quantityinflammatory bowel disease
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. · Nat Genet (2017)Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer. · Cancer Cell (2021)Common variants in Alzheimer's disease and risk stratification by polygenic risk scores. · Nat Commun (2021)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Biosynth | F502-126497-01 | 70R-31043 | PLCG2 antibody (Tyr753) | Rabbit | Polyclonal | PLCG2 antibody detects endogenous levels of PLCG2 only when phosphorylated at tyrosine 753; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-135844-01 | 70R-51315 | PLCG2 antibody | Rabbit | Polyclonal | Recognizes endogenous levels of PLC gamma 2 protein; Cross: Mouse, Rat, Monkey | WB | 100 ul | |
| Biosynth | F502-131492-01 | 70R-36477 | PLCG2 antibody (Tyr1217) | Rabbit | Polyclonal | Human, Mouse, Rat; Cross: Mouse, Rat - Reactive with proteins phosphorylated as follows: Human: Tyr1217, Mouse: Tyr1217, Rat: Tyr1217 | ELISA, IHC, IF, WB | 0.1 mg | |
| Biosynth | F502-126498-01 | 70R-31044 | PLCG2 antibody | Rabbit | Polyclonal | PLCG2 antibody detects endogenous levels of total PLCG2 protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-132311-01 | 70R-37392 | PLCG2 antibody (Tyr1217) | Rabbit | Polyclonal | Human; Cross: Mouse, Rat | IHC | 0.1 mg | |
| Biosynth | F502-132160-01 | 70R-37250 | PLCG2 antibody (Tyr753) | Rabbit | Polyclonal | PLCG2 antibody (Tyr753) detects endogenous levels of PLCG2 only when phosphorylated at tyrosine 753; Cross: Mouse, Rat | WB | 0.1 mg | |
| Biosynth | F502-130762-01 | 70R-35592 | PLCG2 antibody | Rabbit | Polyclonal | PLCG2 antibody detects endogenous levels of total PLCG2 protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Cloud-Clone | T813-125438-01 | PAD841Hu01 | Polyclonal Antibody to Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) | Rabbit | Polyclonal | Human | WB | 100µl | |
| Cloud-Clone | T813-114602-01 | MAD841Hu21 | Monoclonal Antibody to Phospholipase C Gamma 2, Phosphatidylinositol Specific (PLCg2) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Biosynth | F502-109155-01 | 20R-2350 | PLCG2 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IF, WB | 0.05 mg | ||
| Biosynth | F502-109439-01 | 20R-2673 | PLCG2 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IF, IHC | 0.05 mg | ||
| Biosynth | F502-108837-01 | 20R-2023 | PLCG2 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IF, WB | 0.05 mg | ||
| Biosynth | F502-108974-01 | 20R-2161 | PLCG2 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IHC | 0.05 mg | ||
| ELK Biotechnology | T376-116700-01 | ES14068 | PLCγ2 (phospho-Tyr759) rabbit pAb | Rabbit | Polyclonal | Human;Mouse | WB;IF;ELISA;IHC | 50μL | |
| ELK Biotechnology | T376-120971-01 | ES6608 | PLC γ2 (phospho Tyr1217) rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;IHC;IF;ELISA | 50μL | |
| ELK Biotechnology | T376-117054-01 | ES1477 | PLC γ2 (phospho Tyr753) rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;IHC;IF;ELISA | 50μL |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
PLCG1
Erythropoietin activates Phospholipase C gamma (PLCG)
LYN
Erythropoietin activates Phospholipase C gamma (PLCG)
SYK
Dectin-2 family
FYN
Dectin-2 family
EPO
Erythropoietin activates Phospholipase C gamma (PLCG)
JAK2
Erythropoietin activates Phospholipase C gamma (PLCG)
EPOR
Erythropoietin activates Phospholipase C gamma (PLCG)
IRS2
Erythropoietin activates Phospholipase C gamma (PLCG)