PER2 — 카탈로그 20건
Gene PER2
NCBI Gene 8864
국내 소싱 가능
20건
유전자 개요
이 유전자는 포유류 뇌의 주요 일주기 조율자인 시각교차상핵(suprachiasmatic nucleus)에서 일주기 패턴으로 발현되는 Period 유전자 계열의 구성원입니다. 이 계열의 유전자들은 운동 활동, 대사, 행동의 일주기 리듬 구성 요소를 지정합니다. 이 유전자는 CLOCK/ARNTL 이합체에 의해 상향 조절되지만, 이후 PER/CRY 이합체를 사용하여 CLOCK/ARNTL과 상호작용하는 피드백 루프에서 이러한 상향 조절을 억제합니다. 이 유전자의 다형성은 특정 암 발병 위험을 증가시킬 수 있으며 수면 장애와 관련이 있습니다.
Degradation of CRY and PER proteinsPhosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genesPhosphorylation and nuclear translocation of the CRY:PER:kinase complexPhosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promotersThe CRY:PER:kinase complex represses transactivation by the BMAL:CLOCK (ARNTL:CLOCK) complex
Familial advanced sleep-phase syndromechronotype measurementpulse wave reflection index measurementX-21807 measurementseptic shockhematocritliver diseaseerythrocyte volume
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer. · Cancer Cell (2020)NAD(+) Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. · Mol Cell (2020)Deregulated expression of the Per1 and Per2 in human gliomas. · Can J Neurol Sci (2010)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| MyBioSource | R247-199737-01 | MBS9133216 | PER2, Polyclonal Antibody | Rabbit | Polyclonal | Mouse | WB | 0.02 mL | |
| MyBioSource | R247-214777-01 | MBS9613102 | PER2, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Dog, Pig, Chicken, Horse | WB; IHC; EIA | 0.05 mL | |
| Biosynth | F502-122318-01 | 70R-19214 | PER2 antibody | Rabbit | Polyclonal | Human; Cross: Human | ELISA, WB | 50 ul | |
| Biosynth | F502-131783-01 | 70R-36832 | Per2 antibody (Ser662) | Rabbit | Polyclonal | Per2 antibody (Ser662) detects endogenous levels of Period Circadian Protein 2 only when phosphorylated at serine 662. The antibody will detect species specific phosphorylation as follows: Human: Ser662, Mouse: Ser659; Cross: Mouse | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-131507-01 | 70R-36494 | PER2 antibody | Rabbit | Polyclonal | PER2 antibody detects endogenous levels of total PER2 protein; Cross: Mouse | IHC, IF, ELISA | 0.1 mg | |
| Cloud-Clone | T813-128166-01 | PAM013Ra01 | Polyclonal Antibody to Period Circadian Protein 2 (PER2) | Rabbit | Polyclonal | Rat | Testing in progress | 100µl | |
| Cloud-Clone | T813-115802-01 | MAM013Ra21 | Monoclonal Antibody to Period Circadian Protein 2 (PER2) | Mouse | Monoclonal | Rat | WB; IHC; ICC; IP. | 100µl | |
| MyBioSource | R247-134720-01 | MBS2400574 | PER2, Monoclonal Antibody | Mouse | Monoclonal | Human | ELISA; Immunohistochemistry (IHC) Paraffin; WB | 0.05 mg | |
| MyBioSource | R247-113265-01 | MBS126915 | Per2, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB | 0.02 mL | |
| MyBioSource | R247-146779-01 | MBS3204702 | PER2, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Horse | WB | 0.1 mL | |
| MyBioSource | R247-191193-01 | MBS8242819 | PER2, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | WB; IHC | 0.03 mL | |
| MyBioSource | R247-212757-01 | MBS9603532 | PER2, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| Biosynth | F502-139229-01 | 70R-8370 | PER2 antibody | Rabbit | Polyclonal | Human; Cross: Predicted: Human, Mouse, Rat, Horse | WB | 100 ul | |
| ELK Biotechnology | T376-121438-01 | ES7897 | Per2 rabbit pAb | Rabbit | Polyclonal | Human;Mouse | IHC;IF;ELISA | 50μL | |
| ELK Biotechnology | T376-121437-01 | ES7896 | Per2 (phospho Ser662) rabbit pAb | Rabbit | Polyclonal | Human;Mouse | WB;IHC;IF;ELISA | 50μL | |
| MyBioSource | R247-194902-01 | MBS853455 | Period Circadian Protein 2 (Per2), Antibody | Human, Mouse | WB; IHC; ELISA | 0.1 mg |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
PER3
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
PER1
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
CRY1
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
RORA
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
CREBBP
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
CLOCK
Phosphorylation of CLOCK, acetylation of BMAL1 (ARNTL) at target gene promoters
CDK5
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex
PPP1CA
Phosphorylation and nuclear translocation of the CRY:PER:kinase complex