취급 제조사 2곳
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유전자 개요
CDKN1B 유전자는 사이클린 의존성 키나아제 저해제(cyclin-dependent kinase inhibitor)를 암호화하며, 이는 CDK 저해제 CDKN1A/p21과 제한적인 유사성을 공유합니다. 이 유전자에 의해 지정된 단백질은 사이클린 E-CDK2 또는 사이클린 D-CDK4 복합체에 결합하여 활성화를 막음으로써 G1 단계에서 세포 주기 진행을 조절합니다. CDK 의존성 인산화(phosphorylation)와 이후 SCF 복합체에 의한 유비퀴틴화(ubiquitination)에 의해 유발되는 이 단백질의 분해는 세포가 휴지기(quiescence)에서 증식 상태로 전환하는 데 필요합니다. 이 유전자의 돌연변이는 다발성 내분비 신생물 제4형(multiple endocrine neoplasia type IV, MEN4)과 관련이 있습니다.
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- 대표 논문 (PubMed) Keratin-17 Promotes p27KIP1 Nuclear Export and Degradation and Offers Potential Prognostic Utility. · Cancer Res (2015)SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells. · J Biol Chem (2011)p27(Kip1) and human cancers: A reappraisal of a still enigmatic protein. · Cancer Lett (2017)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| MyBioSource | R247-214955-01 | MBS9614053 | p27 Kip1 (p27Kip1), Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Bovine, Dog, Sheep | WB; IHC; IF; ICC; EIA | 0.05 mL | |
| MyBioSource | R247-214954-01 | MBS9614052 | p27 Kip1 (p27Kip1), Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Bovine, Dog, Sheep, Chicken | WB; IHC; IF; ICC; EIA | 0.05 mL | |
| Biosynth | F502-132522-01 | 70R-37587 | p27Kip1 antibody | Rabbit | Polyclonal | Human; Cross: Mouse, Rat | WB, IHC | 0.1 mg | |
| Biosynth | F502-129642-01 | 70R-34321 | p27Kip1 antibody | Rabbit | Polyclonal | p27Kip1 antibody detects endogenous levels of total p27Kip1 protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-132188-01 | 70R-37276 | p27Kip1 antibody (Thr187) | Rabbit | Polyclonal | p27Kip1 antibody (Thr187) detects endogenous levels of p27Kip1 only when phosphorylated at threonine 187; Cross: Mouse, Rat | WB | 0.1 mg | |
| Biosynth | F502-129643-01 | 70R-34322 | p27Kip1 antibody (Thr187) | Rabbit | Polyclonal | p27Kip1 antibody detects endogenous levels of p27Kip1 only when phosphorylated at Threonine 187; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Biosynth | F502-133885-01 | 70R-49528 | p27 Kip1 antibody | Rabbit | Polyclonal | Recognizes endogenous levels of p27 Kip1 protein; Cross: Mouse, Bovine, Dog | WB, IHC | 100 ul | |
| Biosynth | F502-129641-01 | 70R-34320 | p27Kip1 antibody (Ser10) | Rabbit | Polyclonal | p27Kip1 antibody detects endogenous levels of p27Kip1 only when phosphorylated at Serine 10; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Biosynth | F502-129644-01 | 70R-34323 | p27Kip1 antibody (Thr187) | Rabbit | Polyclonal | p27Kip1 antibody detects endogenous levels of total p27Kip1 protein; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Biosynth | F502-133884-01 | 70R-49527 | p27 Kip1 antibody | Rabbit | Polyclonal | Recognizes endogenous levels of p27 Kip1 protein; Cross: Mouse, Rat, Bovine, Dog, Pig, Rabbit | WB | 100 ul | |
| MyBioSource | R247-208035-01 | MBS9406368 | p27Kip1, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB; IHC | 0.05 mL | |
| Biosynth | F502-109128-01 | 20R-2323 | p27Kip1 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IHC, WB | 0.05 mg | ||
| Biosynth | F502-108864-01 | 20R-2050 | p27Kip1 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IHC, WB | 0.05 mg | ||
| Biosynth | F502-106788-01 | 10R-7887 | p27Kip1 antibody | Mouse | Monoclonal | WB, ICC | 0.1 mg |