MSH3 — 카탈로그 17건
Gene MSH3
NCBI Gene 4437
취급 제조사 2곳
국내 소싱 가능
17건
유전자 개요
이 유전자가 암호화하는 단백질은 MSH2와 이합체(heterodimer)를 형성하여 MutS beta를 구성하며, 이는 복제 후 DNA 불일치 복구 시스템(post-replicative DNA mismatch repair system)의 일부이다. MutS beta는 불일치에 결합한 후 MutL alpha 이합체와 복합체를 형성함으로써 불일치 복구를 개시한다. 이 유전자는 첫 번째 엑손(exon)에 다형성(polymorphic) 9 bp 이중 반복 서열(tandem repeat sequence)을 포함한다. 해당 반복 서열은 참조 게놈 서열에 6회 존재하며, 3-7회의 반복이 보고되었다. 이 유전자의 결함은 자궁내막암(endometrial cancer)에 대한 감수성의 원인이 된다.
Defective Mismatch Repair Associated With MSH2Defective Mismatch Repair Associated With MSH3Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
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데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Eukaryotic DNA mismatch repair. · Curr Opin Genet Dev (1999)Microsatellite instability in colorectal cancer. · Acta Biomed (2018)Exome Sequencing Identifies Biallelic MSH3 Germline Mutations as a Recessive Subtype of Colorectal Adenomatous Polyposis. · Am J Hum Genet (2016)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| MyBioSource | R247-149608-01 | MBS3905428 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Human | IP | 0.01 mg | |
| MyBioSource | R247-213092-01 | MBS9605080 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB; IF; ICC; ELISA | 0.1 mL | |
| MyBioSource | R247-149610-01 | MBS3905453 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB; IP | 0.01 mg | |
| MyBioSource | R247-213817-01 | MBS9608093 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Human, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| Biosynth | F502-129113-01 | 70R-33837 | MSH3 antibody | Rabbit | Polyclonal | MSH3 antibody detects endogenous levels of total MSH3 protein | WB, ELISA | 0.1 mg | |
| MyBioSource | R247-191023-01 | MBS8237727 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB; IHC | 0.03 mL | |
| MyBioSource | R247-179288-01 | MBS7197432 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Ashbya gossypii (strain 10895, CBS 109.51, FGSC 9923, NRRL Y-1056)(Yeast)(Eremothec | ELISA; WB (Western Blot) | ||
| MyBioSource | R247-177396-01 | MBS7140382 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Mouse | ELISA; WB (Western Blot) | ||
| MyBioSource | R247-152420-01 | MBS4504789 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB; IHC | 0.05 mL | |
| MyBioSource | R247-176641-01 | MBS7123998 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | ELISA; WB; IHC | 0.05 mL | |
| MyBioSource | R247-177397-01 | MBS7140383 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Saccharomyces cerevisiae (strain YJM789)(Baker's yeast) | ELISA; WB (Western Blot) | ||
| MyBioSource | R247-177398-01 | MBS7140384 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Saccharomyces cerevisiae (strain 204508, S288c)(Baker's yeast) | ELISA; WB (Western Blot) | ||
| MyBioSource | R247-198476-01 | MBS9125389 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB; IHC | 0.02 mL | |
| MyBioSource | R247-177399-01 | MBS7140385 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Schizosaccharomyces pombe (strain 972, 24843)(Fission yeast) | ELISA; WB (Western Blot) | ||
| MyBioSource | R247-202664-01 | MBS9239912 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB; IHC | 0.05 mL | |
| MyBioSource | R247-212828-01 | MBS9603900 | MSH3, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IF; ICC | 0.1 mL |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
MSH6
Defective Mismatch Repair Associated With MSH2
RPA1
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
MLH1
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
RPA2
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
LIG1
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
EXO1
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)