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유전자 개요
이 유전자가 암호화하는 단백질은 이중 특이성 단백질 키나아제(dual specificity protein kinase) 계열에 속하며, MAP 키나아제 키나아제(MAP kinase kinase)로 작용한다. MAP 키나아제(MAP kinase)는 세포외 신호 조절 키나아제(ERK)로도 알려져 있으며, 다양한 생화학적 신호의 통합점 역할을 한다. 이 키나아제는 MAP 키나아제 상위에서 세포 외부 및 내부 신호에 반응해 MAP 키나아제의 효소 활성을 촉진하고, MAP 키나아제 신호전달 경로의 핵심 요소로서 증식, 분화, 전사(transcription) 조절, 발달에 관여한다.
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- 대표 논문 (PubMed) RAF-MEK-ERK pathway in cancer evolution and treatment. · Semin Cancer Biol (2022)Pharmacological inhibitors of MAPK pathways. · Trends Pharmacol Sci (2002)Efficacy of MEK inhibition in patients with histiocytic neoplasms. · Nature (2019)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Abbexa | F158-105103-01 | abx119300 | MEK1 (pT291) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB | 10 µg | |
| Abbexa | F158-101715-01 | abx031877 | MEK1 (pS218 / 222) Antibody | Rabbit | Polyclonal | Human | ELISA, WB, IHC, DB | 80 µl | |
| Abbexa | F158-101963-01 | abx033790 | Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Antibody | Rabbit | Polyclonal | Human, Mouse | ELISA, WB, IHC | 80 µl | |
| Abbexa | F158-101964-01 | abx033791 | Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Antibody | Rabbit | Polyclonal | Human | ELISA, WB | 80 µl | |
| Abbexa | F158-101744-01 | abx032048 | MEK1 (pS222) Antibody | Rabbit | Polyclonal | Human | ELISA, WB, DB | 80 µl | |
| Abbexa | F158-111078-01 | abx235112 | Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA, WB, IHC, IF/ICC | 100 µg | |
| Abbexa | F158-101953-01 | abx033754 | Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Antibody | Rabbit | Polyclonal | Human | ELISA, WB, IHC | 80 µl | |
| Abbexa | F158-102160-01 | abx037455 | Dual Specificity Mitogen-Activated Protein Kinase Kinase 1 (MEK1) Antibody | Rabbit | Polyclonal | Human | ELISA, WB, IHC | 100 µg | |
| Enzo Life Sciences | R365-100349-01 | ADI-KAP-MA010-E | MEK1 polyclonal antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Xenopus | IF, IHC, WB | 100 µg | |
| MyBioSource | R247-210318-01 | MBS9456141 | MEK1, Monoclonal Antibody | Rabbit | Monoclonal | Human, Mouse, Rat | Most Applications | 0.1 mL | |
| Biosynth | F502-129581-01 | 70R-34265 | MEK1 antibody | Rabbit | Polyclonal | MEK1 antibody detects endogenous levels of total MEK1 protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-130653-01 | 70R-35460 | MEK1 antibody | Rabbit | Polyclonal | MEK1 antibody detects endogenous levels of total MEK1 protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-130760-01 | 70R-35590 | MEK1 antibody (Ser298) | Rabbit | Polyclonal | Human, Mouse, Rat; Cross: Mouse, Rat - Reactive with proteins phosphorylated as follows: Human: Ser298, Mouse: Ser298, Rat: Ser298 | WB, ELISA | 0.1 mg | |
| Biosynth | F502-129578-01 | 70R-34262 | MEK1 antibody (Ser221) | Rabbit | Polyclonal | MEK1 antibody detects endogenous levels of MEK1 only when phosphorylated at serine 221; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-132267-01 | 70R-37348 | MEK1 antibody (Thr291) | Rabbit | Polyclonal | Human; Cross: Mouse, Rat | WB | 0.1 mg | |
| Biosynth | F502-132146-01 | 70R-37238 | MEK1 antibody (Ser221) | Rabbit | Polyclonal | MEK1 antibody (Ser221) detects endogenous levels of MEK1 only when phosphorylated at serine 221; Cross: Mouse, Rat | WB, IHC | 0.1 mg | |
| Biosynth | F502-130240-01 | 70R-34950 | MEK1 antibody (Thr286) | Rabbit | Polyclonal | Human, Mouse, Rat; Cross: Mouse, Rat. Specific detection of phosphorylated Human: Thr286, Mouse: Thr286, Rat: Thr286 | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-129579-01 | 70R-34263 | MEK1 antibody | Rabbit | Polyclonal | MEK1 antibody detects endogenous levels of total MEK1 protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-131900-01 | 70R-36980 | MEK1 antibody | Rabbit | Polyclonal | MEK1 antibody detects endogenous levels of total MEK1 protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-129577-01 | 70R-34261 | MEK1 antibody | Rabbit | Polyclonal | MEK1 antibody detects endogenous levels of total MEK1 protein; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Biosynth | F502-132186-01 | 70R-37274 | MEK1 antibody (Ser217) | Rabbit | Polyclonal | MEK1 antibody (Ser217) detects endogenous levels of MEK1 only when phosphorylated at serine 217; Cross: Mouse, Rat | IHC | 0.1 mg | |
| Biosynth | F502-129580-01 | 70R-34264 | MEK1 antibody (Thr291) | Rabbit | Polyclonal | MEK1 antibody detects endogenous levels of MEK1 only when phosphorylated at threonine 291; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| Biosynth | F502-129576-01 | 70R-34260 | MEK1/2 antibody (Ser218/222) | Rabbit | Polyclonal | MEK1/2 antibody detects endogenous levels of MEK1 only when phosphorylated at serine Ser218/222; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| MyBioSource | R247-214339-01 | MBS9610709 | MEK1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Bovine, Dog, Pig, Sheep, Chicken, Horse | WB; IHC; EIA | 0.05 mL | |
| MyBioSource | R247-214427-01 | MBS9611134 | MEK1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Bovine, Dog, Pig, Sheep, Chicken, Zebrafish, Horse | WB; EIA | 0.05 mL | |
| Biosynth | F502-109512-01 | 20R-2748 | MEK1/2 antibody | Rabbit | Human, Mouse, Rat | WB | 0.05 mg | ||
| Biosynth | F502-108825-01 | 20R-2011 | MEK1 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IF, IHC, WB | 0.05 mg | ||
| Biosynth | F502-109245-01 | 20R-2441 | MEK1 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IHC, WB | 0.05 mg | ||
| Biosynth | F502-108862-01 | 20R-2048 | MEK1/MEK2 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IHC, WB | 0.05 mg | ||
| Biosynth | F502-108934-01 | 20R-2121 | MEK1 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | WB | 0.05 mg | ||
| Biosynth | F502-109171-01 | 20R-2366 | MEK1/MEK2 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IF, IHC, WB | 0.05 mg | ||
| Biosynth | F502-109147-01 | 20R-2342 | MEK1 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IHC, WB | 0.05 mg |