유전자 개요
이 유전자는 MAP 키나아제(MAP kinase) 계열 단백질을 암호화한다. MAP 키나아제는 세포 외 신호 조절 키나아제(extracellular signal-regulated kinases, ERKs)로도 알려져 있으며, 다양한 세포 외 신호에 반응하여 증식, 분화, 세포 주기(cell cycle) 진행 등 여러 세포 과정을 조절하는 신호 전달 연쇄 과정에서 작용한다. 이 키나아제(kinase)는 상위 키나아제에 의해 활성화되어 세포핵(nucleus)으로 이동하며, 세포핵 내 표적 단백질을 인산화시킨다. 서로 다른 단백질 등형체를 암호화하는 대체 접합 전사체 변이체들이 보고된 바 있다.
Activation of the AP-1 family of transcription factorsAdvanced glycosylation endproduct receptor signalingDownregulation of SMAD2/3:SMAD4 transcriptional activityERK/MAPK targetsERKs are inactivatedESR-mediated signalingEstrogen-dependent nuclear events downstream of ESR-membrane signalingFCERI mediated MAPK activationFCGR3A-mediated phagocytosisFrs2-mediated activation
cancerNoonan syndromehypertrophic cardiomyopathyCostello syndromehemoglobin measurementamygdala volumehematocritsugar consumption measurement
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) MAPK1/3 kinase-dependent ULK1 degradation attenuates mitophagy and promotes breast cancer bone metastasis. · Autophagy (2021)GDF15 promotes the proliferation of cervical cancer cells by phosphorylating AKT1 and Erk1/2 through the receptor ErbB2. · J Exp Clin Cancer Res (2018)Highly-metastatic colorectal cancer cell released miR-181a-5p-rich extracellular vesicles promote liver metastasis by activating hepatic stellate cells and remodelling the tumour microenvironment. · J Extracell Vesicles (2022)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cusabio | T094-106705-01 | CSB-PA013456LA01HU | MAPK3 Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA, WB, IHC, IF | 50μg, 100μg | |
| Cusabio | T094-109545-01 | CSB-RA013456A185phHU | Phospho-MAPK3 (T202) + MAPK1 (T185) Recombinant Monoclonal Antibody | Rabbit | Monoclonal | Human | ELISA, WB, IHC, IF | 50μl, 100μl | |
| Abbexa | F158-110067-01 | abx227045 | Mitogen-Activated Protein Kinase 3 / ERK1 (MAPK3) Antibody | Rabbit | Monoclonal | Human, Mouse, Rat | ELISA, WB, IF/ICC, IP | 20 µl | |
| MyBioSource | R247-188982-01 | MBS806805 | Erk1/2 (Mapk3), Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Bovine, Sheep, Chicken | WB; IHC; ICC; IF; FC | 0.1 mL | |
| MyBioSource | R247-212143-01 | MBS9600418 | MAPK3, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| MyBioSource | R247-213021-01 | MBS9604764 | MAPK3, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| MyBioSource | R247-212978-01 | MBS9604597 | p44 MAPK (MAPK3), Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IF; ICC; ELISA | 0.1 mL | |
| Biosynth | F502-127457-01 | 70R-31926 | MAPK3 antibody | Rabbit | Polyclonal | MAPK3 antibody detects endogenous levels of total MAPK3 protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-117235-01 | 70R-13885 | MAPK3 antibody | Rabbit | Polyclonal | Human | WB, IHC-P, ICC | 0.1 mg | |
| Biosynth | F502-102896-01 | 10R-1188 | MAPK3 antibody | Mouse | Monoclonal | Human; Cross: To be determined by end-user. | ELISA, IF, WB | 100 ul | |
| MyBioSource | R247-200809-01 | MBS9200061 | MAPK3, Monoclonal Antibody | Mouse | Monoclonal | Human, Mouse | WB; ELISA | 0.08 mL | |
| MyBioSource | R247-208082-01 | MBS9407208 | MAPK3, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC | 0.05 mL | |
| MyBioSource | R247-113764-01 | MBS128336 | MAPK3-Y204, Antibody | Rabbit | Human, Mouse, Rat | WB; IHC; IF | 0.02 mL | ||
| Biosynth | F502-136791-01 | 70R-5573 | MAPK3 antibody | Rabbit | Polyclonal | MAPK3 antibody was raised against the middle region of MAPK3; Cross: Human,Mouse,Rat | WB | 100 ul | |
| Biosynth | F502-136792-01 | 70R-5574 | MAPK3 antibody | Rabbit | Polyclonal | MAPK3 antibody was raised against the middle region of MAPK3; Cross: Human,Mouse,Rat | WB | 100 ul |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.