KEAP1 — 카탈로그 24건
Gene KEAP1
NCBI Gene 9817
국내 소싱 가능
24건
유전자 개요
이 유전자는 산화 및 친전자성 스트레스에 대한 세포 반응에 관여하는 세포질 조절 단백질을 암호화합니다. 해당 단백질은 항산화 및 세포 보호 유전자의 발현을 조절하는 전사인자(transcription factor)인 NRF2를 조절합니다. 스트레스가 없는 조건에서는 KEAP1이 NRF2에 결합하여 유비퀴틴화(ubiquitination) 및 프로테아좀 분해를 촉진하며, 이를 통해 NRF2 수준을 낮게 유지합니다.
Antigen processing: Ubiquitination & Proteasome degradationKEAP1-NFE2L2 pathwayNeddylationNuclear events mediated by NFE2L2Potential therapeutics for SARSUb-specific processing proteases
multiple sclerosislung adenocarcinomarelapsing-remitting multiple sclerosisnon-small cell lung carcinomasquamous cell lung carcinomapsoriasishepatocellular carcinomaimmune system disease
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Nrf2-Keap1 signaling in oxidative and reductive stress. · Biochim Biophys Acta Mol Cell Res (2018)The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis. · Physiol Rev (2018)Proteasomal and Autophagic Degradation Systems. · Annu Rev Biochem (2017)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cusabio | T094-106620-01 | CSB-PA012147LA01HU | KEAP1 Antibody | Rabbit | Polyclonal | Human, Mouse | ELISA, WB, IHC | 50μg, 100μg | |
| Biosynth | F502-104787-01 | 10R-4530 | KEAP1 antibody | Mouse | Monoclonal | Human; Cross: Human | FC, WB | 100 ul | |
| Biosynth | F502-104786-01 | 10R-4529 | KEAP1 antibody | Mouse | Monoclonal | Human; Cross: Human | FC, IF, WB | 100 ul | |
| Biosynth | F502-106549-01 | 10R-7009 | KEAP1 antibody | Mouse | Monoclonal | Human; Cross: Human, Mouse | IHC, FC, WB | 100 ul | |
| Biosynth | F502-121098-01 | 70R-18096 | KEAP1 antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, IHC, WB | 50 ul | |
| Cloud-Clone | T813-115761-01 | MAL648Hu21 | Monoclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-128081-01 | PAL648Mu01 | Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) | Rabbit | Polyclonal | Murine | WB; ICC/IF | 100µl | |
| Cloud-Clone | T813-128080-01 | PAL648Hu01 | KO-Validated Polyclonal Antibody to Kelch Like ECH Associated Protein 1 (KEAP1) | Rabbit | Polyclonal | Human | WB; ICC/IF | 100µl | |
| MyBioSource | R247-146629-01 | MBS3202247 | KEAP1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Dog, Pig, Zebrafish, Horse | IHC; WB | 0.1 mL | |
| MyBioSource | R247-146754-01 | MBS3204380 | KEAP1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Pig, Horse | WB; IHC | 0.1 mL | |
| Biosynth | F502-108402-01 | 20R-1096 | KEAP1 antibody | Rabbit | Human; Cross: Predicted: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit | IHC, WB | 100 ul | ||
| MyBioSource | R247-137857-01 | MBS2542563 | KEAP1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA; IHC | ||
| Biosynth | F502-139155-01 | 70R-8295 | KEAP1 antibody | Rabbit | Polyclonal | Human; Cross: Predicted: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit | IHC, WB | 100 ul | |
| Biosynth | F502-138917-01 | 70R-8050 | KEAP1 antibody | Rabbit | Polyclonal | Human; Cross: Predicted: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit, Zebrafish | IHC, WB | 100 ul | |
| ELK Biotechnology | T376-119691-01 | ES3948 | Keap-1 rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;IHC;IF;ELISA | 50μL | |
| MyBioSource | R247-118591-01 | MBS1492106 | Keap1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | ELISA; WB | 0.05 mg |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
SQSTM1
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NFE2L2
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CDKN2A
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EP300
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CREBBP
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PRKAA2
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MAFK
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AKT1
KEAP1-NFE2L2 pathway