KDM1A — 카탈로그 35건
Gene KDM1A
NCBI Gene 23028
취급 제조사 2곳
국내 소싱 가능
35건
유전자 개요
이 유전자는 SWIRM 도메인, FAD-결합 모티프, 아민 산화효소 도메인을 포함하는 핵 단백질을 암호화한다. 이 단백질은 여러 히스톤 탈아세틸화효소 복합체의 구성 요소이지만, 히스톤 탈메틸화효소로 작용하여 유전자를 침묵시킨다. 대안적 스플라이싱은 여러 전사체 변이체를 생성한다.
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3Estrogen-dependent gene expressionFactors involved in megakaryocyte development and platelet productionHDACs deacetylate histonesHDMs demethylate histonesNR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and effluxNegative Regulation of CDH1 Gene TranscriptionPotential therapeutics for SARSRegulation of PTEN gene transcription
palatal anomalies-widely spaced teeth-facial dysmorphism-developmental delay syndromeneurodegenerative diseaseACTH-independent macronodular adrenal hyperplasia 3alkaline phosphatase measurementserum gamma-glutamyl transferase measurementCushing syndrome due to macronodular adrenal hyperplasiadevelopmental disabilitylow density lipoprotein cholesterol measurement
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. · Cell (2004)LSD1/KDM1A inhibitors in clinical trials: advances and prospects. · J Hematol Oncol (2019)ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia. · Cancer Cell (2018)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
HDAC3
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
HDAC1
Regulation of PTEN gene transcription
HDAC2
Regulation of PTEN gene transcription
RBBP4
Regulation of PTEN gene transcription
NCOR2
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NCOR1
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
MAPK1
Regulation of PTEN gene transcription
SNAI1
Regulation of PTEN gene transcription