KCNJ5 — 카탈로그 11건
Gene KCNJ5
NCBI Gene 3762
국내 소싱 가능
11건
Activation of G protein gated Potassium channelsInhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
familial hyperaldosteronism type IIIatrial fibrillationheart ratealdosterone-producing adenomaProlonged QT intervalatrial flutterlong QT syndrome 13cardiac arrhythmia
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) An International, Multicentered, Evidence-Based Reappraisal of Genes Reported to Cause Congenital Long QT Syndrome. · Circulation (2020)Effect of KCNJ5 mutations on gene expression in aldosterone-producing adenomas and adrenocortical cells. · J Clin Endocrinol Metab (2012)Role of KCNJ5 in familial and sporadic primary aldosteronism. · Nat Rev Endocrinol (2013)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
GNB1
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
KCNJ2
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GNB2
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
KCNJ12
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GNB3
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GNG2
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GABBR1
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
KCNJ10
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits