KCNJ10 — 카탈로그 10건
Gene KCNJ10
NCBI Gene 3766
취급 제조사 4곳
국내 소싱 가능
10건
유전자 개요
이 유전자는 세포 내로의 칼륨(potassium) 흐름에 더 큰 경향을 보이는 안쪽으로 향하는 전류형 칼륨 채널(inward rectifier-type potassium channel) 패밀리의 구성원을 암호화한다. 해당 단백질은 다른 칼륨 채널 단백질과 이종이량체(heterodimer)를 형성할 수 있으며, 뇌에서 신경교세포(glial cells)의 칼륨 완충 작용을 담당할 수 있다. 이 유전자의 돌연변이는 일반적인 특발성 전신 발작 증후군(idiopathic generalized epilepsy syndromes)의 발작 감수성과 관련이 있었다.
Activation of G protein gated Potassium channelsInhibition of voltage gated Ca2+ channels via Gbeta/gamma subunitsPotassium transport channels
EAST syndromeautosomal recessive nonsyndromic hearing loss 4Pendred syndromehearing loss, autosomal recessivehypercoagulability syndrome due to glycosylphosphatidylinositol deficiencynonsyndromic genetic hearing lossepisodic kinesigenic dyskinesia 1episodic kinesigenic dyskinesia
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) KCNJ10 gene mutations causing EAST syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) disrupt channel function. · Proc Natl Acad Sci U S A (2010)Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human Kir4.1 gene (KCNJ10). · Glia (2011)Association between variation in the human KCNJ10 potassium ion channel gene and seizure susceptibility. · Epilepsy Res (2004)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Biosynth | F502-121075-01 | 70R-18075 | KCNJ10 antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, WB | 50 ul | |
| Cloud-Clone | T813-115916-01 | MAP930Hu21 | Monoclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 10 (KCNJ10) | Mouse | Monoclonal | Human | IHC | 100µl | |
| Cloud-Clone | T813-128439-01 | PAP930Hu01 | Polyclonal Antibody to Potassium Inwardly Rectifying Channel Subfamily J, Member 10 (KCNJ10) | Rabbit | Polyclonal | Human | Testing in progress. | 100µl | |
| MyBioSource | R247-119018-01 | MBS1496426 | ATP-sensitive inward rectifier potassium channel 10 (KCNJ10), Polyclonal Antibody | Rabbit | Polyclonal | Human | ELISA; IHC; IF | 0.05 mg |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
GNB1
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
KCNJ2
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GNB2
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
KCNJ12
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GNB3
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GNG2
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GABBR1
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
KCNJ5
Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits