IRF3 — 카탈로그 30건
Gene IRF3
NCBI Gene 3661
국내 소싱 가능
30건
유전자 개요
인터페론 조절 전사인자(IRF) 계열 단백질을 암호화하는 유전자이다. 이 유전자가 지정하는 단백질은 비활성 세포질 형태로 존재하며, 세린/트레오닌 인산화(phosphorylation)를 거쳐 CREBBP와 복합체를 형성한다. 이 복합체는 세포핵(nucleus)으로 이동하여 인터페론 알파와 베타 및 다른 인터페론 유도 유전자의 전사(transcription)를 활성화시킨다. 이 단백질은 DNA 및 RNA 바이러스에 대한 선천 면역 반응에서 중요한 역할을 한다.
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)DDX58/IFIH1-mediated induction of interferon-alpha/betaEvasion by RSV of host interferon responsesIRF3 mediated activation of type 1 IFNIRF3-mediated induction of type I IFNISG15 antiviral mechanismInterferon alpha/beta signalingInterferon gamma signalingLRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN productionNegative regulators of DDX58/IFIH1 signaling
Herpetic encephalitissevere acute respiratory syndromeCOVID-19neurodegenerative diseaseschizophreniaskin neoplasmhypothyroidismbasal cell carcinoma
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. · Nat Immunol (2003)Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation. · Science (2015)The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. · Immunity (2008)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cusabio | T094-109529-01 | CSB-RA011818A386phHU | Phospho-IRF3 (S386) Recombinant Monoclonal Antibody | Rabbit | Monoclonal | Human | ELISA, WB | 50μl, 100μl | |
| MyBioSource | R247-214939-01 | MBS9613999 | IRF3, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | IF; ICC; EIA | 0.1 mL | |
| MyBioSource | R247-214755-01 | MBS9612978 | IRF3, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | IF; ICC; EIA | 0.1 mL | |
| MyBioSource | R247-127825-01 | MBS2026221 | Interferon Regulatory Factor 3 (IRF3), Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; ICC; Immunohistochemistry (IHC) Formalin/Paraffin; ELISA | 0.1 mL | |
| MyBioSource | R247-211208-01 | MBS9503596 | IRF3, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB; IHC; IF; ELISA | 0.05 mL | |
| Biosynth | F502-102485-01 | 10R-1058 | IRF3 antibody | Mouse | Monoclonal | Human; Cross: To be determined by end-user. | ELISA, IF, IP, WB | 100 ul | |
| Biosynth | F502-131569-01 | 70R-36574 | IRF3 antibody (Ser385) | Rabbit | Polyclonal | Human, Mouse, Rat; Cross: Mouse, Rat - Reactive with proteins phosphorylated as follows: Human: Ser385, Mouse: Ser387, Rat: Ser380 | ELISA, IHC, IF, WB | 0.1 mg | |
| Biosynth | F502-128358-01 | 70R-32755 | IRF3 antibody | Rabbit | Polyclonal | IRF3 antibody detects endogenous levels of total IRF3 protein | WB, ELISA | 0.1 mg | |
| Biosynth | F502-102910-01 | 10R-1207 | IRF3 antibody | Mouse | Monoclonal | Human; Cross: Human. Other species not studied | Dot Blot, ICC, IP, WB, FC | 0.1 mg | |
| Biosynth | F502-130998-01 | 70R-35868 | IRF3 antibody | Rabbit | Polyclonal | IRF3 antibody detects endogenous levels of total IRF3 protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-130452-01 | 70R-35220 | IRF3 antibody (Ser396) | Rabbit | Polyclonal | Human, Mouse, Rat; Cross: Mouse, Rat. Specific detection of phosphorylated Human: Ser396, Mouse: Ser388, Rat: Ser390 | WB, ELISA | 0.1 mg | |
| Biosynth | F502-131021-01 | 70R-35894 | IRF3 antibody | Rabbit | Polyclonal | IRF3 antibody detects endogenous levels of total IRF3 protein; Cross: Mouse, Rat | ELISA, IHC, IF, WB | 0.1 mg | |
| Biosynth | F502-121001-01 | 70R-18007 | IRF3 antibody | Rabbit | Polyclonal | Human; Cross: Human | ELISA, IHC, IF, WB | 50 ul | |
| Biosynth | F502-104746-01 | 10R-4473 | IRF3 antibody | Mouse | Monoclonal | Human; Cross: Human | IF, IHC, WB | 100 ul | |
| Biosynth | F502-128357-01 | 70R-32754 | IRF3 antibody (Ser386) | Rabbit | Polyclonal | IRF3 antibody detects endogenous levels of IRF3 only when phosphorylated at serine 386 | WB, ELISA | 0.1 mg | |
| Cloud-Clone | T813-121752-01 | PAB589Mu02 | Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) | Rabbit | Polyclonal | Murine | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-113266-01 | MAB589Hu22 | Monoclonal Antibody to Interferon Regulatory Factor 3 (IRF3) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-121751-01 | PAB589Mu01 | Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) | Rabbit | Polyclonal | Murine | WB; IHC; ICC/IF | 100µl | |
| Cloud-Clone | T813-121750-01 | PAB589Hu01 | Polyclonal Antibody to Interferon Regulatory Factor 3 (IRF3) | Rabbit | Polyclonal | Human | WB; ICC/IF; FCM | 100µl | |
| ELK Biotechnology | T376-120711-01 | ES5922 | IRF-3 (phospho Ser386) rabbit pAb | Rabbit | Polyclonal | Human;Rat;Mouse; | WB;IHC | 50μL | |
| ELK Biotechnology | T376-120710-01 | ES5921 | IRF-3 (phospho Ser396) rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;IHC | 50μL | |
| ELK Biotechnology | T376-120712-01 | ES5924 | IRF-3 rabbit pAb | Rabbit | Polyclonal | Human;Rat;Mouse;;Pig | WB;IHC;IF;ELISA | 50μL | |
| MyBioSource | R247-195640-01 | MBS856015 | IRF-3, Antibody | Human, Mouse, Rat | WB; IHC; IF; ELISA | 0.1 mg |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
TBK1
IRF3 mediated activation of type 1 IFN
UBB
TICAM1-dependent activation of IRF3/IRF7
EP300
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
CREBBP
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
IKBKE
TICAM1-dependent activation of IRF3/IRF7
ZBP1
IRF3 mediated activation of type 1 IFN
IRF7
TICAM1-dependent activation of IRF3/IRF7
TRAF3
TICAM1-dependent activation of IRF3/IRF7