IRAK1 — 카탈로그 33건
Gene IRAK1
NCBI Gene 3654
국내 소싱 가능
33건
유전자 개요
이 유전자는 인터루킨-1 수용체(IL1R)와 연관되어 인터루킨-1 수용체-연관 키나아제 1을 암호화한다. 이 단백질은 인터루킨-1 수용체와 결합하는 두 개의 세린/트레오닌 키나아제 중 하나이다. 이 유전자는 또한 인터루킨-1 유도 전사(transcription) 인자 NF-kappa B의 상향 조절에 부분적으로 관여한다. 서로 다른 아이소폼(isoform)을 암호화하는 대체 스플라이싱 전사 변이체(transcript variant)들이 발견되었다.
IRAK1 recruits IKK complexIRAK1 recruits IKK complex upon TLR7/8 or 9 stimulationInterleukin-1 signalingJNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1MyD88 cascade initiated on plasma membraneMyD88 dependent cascade initiated on endosomeMyD88:MAL(TIRAP) cascade initiated on plasma membraneNF-kB is activated and signals survivalNOD1/2 Signaling PathwayPI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
neurodegenerative diseasesystemic lupus erythematosusmultiple myelomaneuroinflammatory disorderRett syndromerheumatoid arthritisautoimmune diseaseneutrophil percentage of leukocytes
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Oncogenically active MYD88 mutations in human lymphoma. · Nature (2011)IRAK1: a critical signaling mediator of innate immunity. · Cell Signal (2008)MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1. · Signal Transduct Target Ther (2023)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| MyBioSource | R247-214817-01 | MBS9613243 | IRAK1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Dog, Horse | WB; IHC; EIA | 0.05 mL | |
| MyBioSource | R247-214758-01 | MBS9612989 | IRAK1, Polyclonal Antibody | Rabbit | Polyclonal | Human | EIA | 0.1 mL | |
| MyBioSource | R247-214929-01 | MBS9613942 | IRAK1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | EIA | 0.1 mL | |
| MyBioSource | R247-214818-01 | MBS9613244 | IRAK1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Bovine, Dog, Pig, Sheep, Zebrafish, Horse | WB; EIA | 0.05 mL | |
| MyBioSource | R247-214848-01 | MBS9613449 | IRAK1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; EIA | 0.05 mL | |
| MyBioSource | R247-214816-01 | MBS9613242 | IRAK1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; EIA | 0.05 mL | |
| MyBioSource | R247-214942-01 | MBS9614010 | IRAK1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Bovine, Dog, Pig, Sheep, Zebrafish, Horse | WB; IHC; EIA | 0.05 mL | |
| MyBioSource | R247-214849-01 | MBS9613450 | IRAK1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Dog, Horse | WB; EIA | 0.05 mL | |
| Biosynth | F502-130989-01 | 70R-35859 | IRAK1 antibody | Rabbit | Polyclonal | IRAK1 antibody detects endogenous levels of total IRAK1 protein; Cross: Mouse | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-131261-01 | 70R-36185 | IRAK1 antibody (Thr100) | Rabbit | Polyclonal | Human, Mouse; Cross: Mouse - Reactive with proteins phosphorylated as follows: Human: Thr100, Mouse: Thr100 | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-128254-01 | 70R-32659 | IRAK1 antibody | Rabbit | Polyclonal | IRAK1 antibody detects endogenous levels of total IRAK1 protein | IHC, ELISA | 0.1 mg | |
| Biosynth | F502-128253-01 | 70R-32658 | IRAK1 antibody (Ser376) | Rabbit | Polyclonal | IRAK1 antibody detects endogenous levels of IRAK1 only when phosphorylated at serine 376 | IHC, ELISA | 0.1 mg | |
| Biosynth | F502-131461-01 | 70R-36438 | IRAK1 antibody (Thr387) | Rabbit | Polyclonal | Human, Mouse, Rat; Cross: Mouse, Rat - Reactive with proteins phosphorylated as follows: Human: Thr387, Mouse: Thr387, Rat: Thr387 | IF, ELISA | 0.1 mg | |
| Biosynth | F502-131101-01 | 70R-35981 | IRAK1 antibody | Rabbit | Polyclonal | IRAK1 antibody detects endogenous levels of total IRAK1 protein; Cross: Mouse | WB, ELISA | 0.1 mg | |
| Biosynth | F502-130805-01 | 70R-35642 | IRAK1 antibody (Thr209) | Rabbit | Polyclonal | Mouse; Cross: Mouse - Reactive with proteins phosphorylated as follows: Mouse: Thr209 | WB, ELISA | 0.1 mg | |
| Biosynth | F502-134321-01 | 70R-49924 | IRAK1 antibody | Rabbit | Polyclonal | Recognizes endogenous levels of IRAK1 protein; Cross: Mouse | WB | 100 ul | |
| Cloud-Clone | T813-113205-01 | MAB514Hu22 | Monoclonal Antibody to Interleukin 1 Receptor Associated Kinase 1 (IRAK1) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-121593-01 | PAB514Hu01 | Polyclonal Antibody to Interleukin 1 Receptor Associated Kinase 1 (IRAK1) | Rabbit | Polyclonal | Human | WB | 100µl | |
| MyBioSource | R247-161618-01 | MBS615736 | IRAK1, Polyclonal Antibody | Goat | Polyclonal | Human | WB | 0.1 mg | |
| MyBioSource | R247-214850-01 | MBS9613451 | IRAK1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Bovine, Dog, Pig, Sheep, Zebrafish, Horse | WB | 0.05 mL | |
| MyBioSource | R247-137750-01 | MBS2539755 | IRAK-1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IF; ELISA | 0.02 mL | |
| ELK Biotechnology | T376-120709-01 | ES5914 | IRAK-1 (phospho Thr209) rabbit pAb | Rabbit | Polyclonal | Human;Rat;Mouse; | WB;ELISA;IHC | 50μL | |
| ELK Biotechnology | T376-119117-01 | ES2641 | IRAK-1 rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;IHC | 50μL |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
TRAF6
MyD88 dependent cascade initiated on endosome
MYD88
MyD88 dependent cascade initiated on endosome
IRAK2
MyD88 dependent cascade initiated on endosome
UBB
p75NTR recruits signalling complexes
IRAK4
MyD88 dependent cascade initiated on endosome
IKBKB
p75NTR recruits signalling complexes
TLR9
MyD88 dependent cascade initiated on endosome
TLR7
MyD88 dependent cascade initiated on endosome