IFNG 유전자는 제2형 인터페론(type II interferon) 계열에 속하는 가용성 사이토카인(cytokine)을 암호화하며, 이 단백질은 선천면역계와 적응면역계 세포 모두에서 분비된다. 활성형 단백질은 동종이량체(homodimer)로서 인터페론 감마 수용체(interferon gamma receptor)에 결합해 바이러스 및 미생물 감염에 대한 세포 반응을 유발한다. 이 유전자의 돌연변이는 바이러스·세균·기생충 감염과 여러 자가면역질환에 대한 감수성 증가와 연관된다.
Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulationIFNG signaling activates MAPKsInterferon gamma signalingRUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)Regulation of IFNG signaling
The minimum detectable dose of sheep IFN-gamma is typically less than 2.5 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest sheep IFN-gamma concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
The minimum detectable dose of rabbit IFN -gamma is typically less than 15.6 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
The minimum detectable dose of bovine IFN -gamma is typically less than 7.81 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
