HDAC2 — 카탈로그 30건
Gene HDAC2
NCBI Gene 3066
국내 소싱 가능
30건
유전자 개요
이 유전자가 암호화하는 단백질은 히스톤 탈아세틸화효소(histone deacetylase) 계열에 속한다. 히스톤 탈아세틸화효소는 거대한 다중 단백질 복합체 형성을 통해 작용하며, 핵심 히스톤(H2A, H2B, H3, H4)의 N-말단 부위 리신 잔기 탈아세틸화를 담당한다. 이 단백질은 포유류 징크 핑거 전사인자(transcription factor)인 YY1을 포함한 다양한 단백질과 결합하여 전사 억제 복합체를 형성한다. 따라서 전사 조절, 세포 주기 진행 및 발달 과정에서 중요한 역할을 수행한다. 대체 스플라이싱(alternative splicing)으로 여러 전사체 변이체가 만들어진다.
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsConstitutive Signaling by NOTCH1 PEST Domain MutantsEGR2 and SOX10-mediated initiation of Schwann cell myelinationERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionFOXO-mediated transcription of oxidative stress, metabolic and neuronal genesFactors involved in megakaryocyte development and platelet productionHDACs deacetylate histonesMECP2 regulates neuronal receptors and channelsNOTCH1 Intracellular Domain Regulates TranscriptionNegative Regulation of CDH1 Gene Transcription
neoplasmmultiple myelomaneurodegenerative diseaseunspecified peripheral T-cell lymphomaCutaneous T-cell lymphomaT-cell non-Hodgkin lymphomasitting height measurementlymphoma
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Coordination of PAD4 and HDAC2 in the regulation of p53-target gene expression. · Oncogene (2010)A feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis. · Genome Biol (2024)YTHDC1 is downregulated by the YY1/HDAC2 complex and controls the sensitivity of ccRCC to sunitinib by targeting the ANXA1-MAPK pathway. · J Exp Clin Cancer Res (2022)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cusabio | T094-110247-01 | CSB-RA949799A0HU | HDAC2 Recombinant Monoclonal Antibody | Rabbit | Monoclonal | Human | ELISA, WB, IHC, IF | 50μl, 100μl | |
| Cusabio | T094-110023-01 | CSB-RA593846A0HU | HDAC2 Recombinant Monoclonal Antibody | Rabbit | Monoclonal | Human | ELISA, WB, IHC | 50μl, 100μl | |
| Biosynth | F502-117241-01 | 70R-13893 | HDAC2 antibody | Rabbit | Polyclonal | Human | WB, IHC-P | 0.1 mg | |
| Biosynth | F502-129473-01 | 70R-34167 | HDAC2 antibody | Rabbit | Polyclonal | HDAC2 antibody detects endogenous levels of total HDAC2 protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-120680-01 | 70R-17705 | HDAC2 antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, IHC, IF, WB | 50 ul | |
| Biosynth | F502-129472-01 | 70R-34166 | HDAC2 antibody (Ser394) | Rabbit | Polyclonal | HDAC2 antibody detects endogenous levels of HDAC2 only when phosphorylated at serine 394; Cross: Mouse | WB, ELISA | 0.1 mg | |
| Biosynth | F502-117240-01 | 70R-13892 | HDAC2 antibody | Rabbit | Polyclonal | Human | WB | 0.1 mg | |
| Biosynth | F502-132174-01 | 70R-37263 | HDAC2 antibody (Ser394) | Rabbit | Polyclonal | HDAC2 antibody (Ser394) detects endogenous levels of HDAC2 only when phosphorylated at serine 394; Cross: Mouse, Rat | WB, IHC, IF | 0.1 mg | |
| Biosynth | F502-132512-01 | 70R-37578 | HDAC2 antibody | Rabbit | Polyclonal | Human; Cross: Mouse, Rat | WB | 0.1 mg | |
| Cloud-Clone | T813-123335-01 | PAC210Ra01 | Polyclonal Antibody to Histone Deacetylase 2 (HDAC2) | Rabbit | Polyclonal | Rat | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-123333-01 | PAC210Mu01 | Polyclonal Antibody to Histone Deacetylase 2 (HDAC2) | Rabbit | Polyclonal | Murine | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-113886-01 | MAC210Hu22 | Monoclonal Antibody to Histone Deacetylase 2 (HDAC2) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-123332-01 | PAC210Hu01 | Polyclonal Antibody to Histone Deacetylase 2 (HDAC2) | Rabbit | Polyclonal | Human | WB; IHC; ICC/IF | 100µl | |
| Cloud-Clone | T813-123334-01 | PAC210Mu02 | Polyclonal Antibody to Histone Deacetylase 2 (HDAC2) | Rabbit | Polyclonal | Murine | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-113887-01 | MAC210Ra21 | Monoclonal Antibody to Histone Deacetylase 2 (HDAC2) | Mouse | Monoclonal | Rat | WB; IHC; ICC; IP. | 100µl | |
| MyBioSource | R247-146515-01 | MBS3201050 | HDAC2, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Rabbit, Dog, Guinea Pig, Pig, Horse | IHC; WB | 0.1 mL | |
| MyBioSource | R247-134769-01 | MBS2401727 | HDAC2, Polyclonal Antibody | Rabbit | Polyclonal | Human | ELISA; Immunohistochemistry (IHC) Paraffin; WB | ||
| Biosynth | F502-109120-01 | 20R-2315 | HDAC2 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IF, IHC, WB | 0.05 mg | ||
| Biosynth | F502-108851-01 | 20R-2037 | HDAC2 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | IF, IHC, WB | 0.05 mg | ||
| Biosynth | F502-100778-01 | 10-3028 | HDAC2 Antibody | Mouse | Monoclonal | Human; Cross: Mouse, Rat, Human | WB , IP, ICC/IF | 0.1 mg | |
| ELK Biotechnology | T376-116750-01 | ES1417 | HDAC2 (phospho Ser394) rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat;Monkey | WB;ELISA | 50μL |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
HDAC1
p75NTR negatively regulates cell cycle via SC1
HDAC3
p75NTR negatively regulates cell cycle via SC1
EP300
STAT3 nuclear events downstream of ALK signaling
NGF
p75NTR negatively regulates cell cycle via SC1
CHD3
Regulation of TP53 Activity through Acetylation
RBBP4
Regulation of TP53 Activity through Acetylation
MTA2
Regulation of TP53 Activity through Acetylation
NOTCH1
MECP2 regulates neuronal receptors and channels