HDAC1 — 카탈로그 35건
Gene HDAC1
NCBI Gene 3065
국내 소싱 가능
35건
유전자 개요
다중 소단위 복합체에 의해 촉매되는 히스톤 아세틸화 및 탈아세틸화는 진핵 유전자 발현 조절에서 핵심적인 역할을 한다. 이 유전자가 암호화하는 단백질은 히스톤 탈아세틸화효소/acuc/apha 계열에 속하며 히스톤 탈아세틸화효소 복합체의 구성 요소이다. 또한 이 단백질은 망막모세포종(retinoblastoma) 종양 억제 단백질과 상호작용하며, 이 복합체는 세포 증식 및 분화 조절의 핵심 요소이다. 전이(metastasis)-연관 단백질-2와 함께 p53을 탈아세틸화하고 세포 성장 및 세포자멸사(apoptosis)에 대한 p53의 효과를 조절한다.
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsConstitutive Signaling by NOTCH1 PEST Domain MutantsDeactivation of the beta-catenin transactivating complexDownregulation of SMAD2/3:SMAD4 transcriptional activityERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionEstrogen-dependent gene expressionFOXO-mediated transcription of oxidative stress, metabolic and neuronal genesFactors involved in megakaryocyte development and platelet productionFormation of the beta-catenin:TCF transactivating complexG0 and Early G1
neoplasmmultiple myelomaunspecified peripheral T-cell lymphomaCutaneous T-cell lymphomaT-cell non-Hodgkin lymphomacancerlymphomaRett syndrome
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining. · Nat Struct Mol Biol (2010)Rutin alleviates EndMT by restoring autophagy through inhibiting HDAC1 via PI3K/AKT/mTOR pathway in diabetic kidney disease. · Phytomedicine (2023)Lactylation of HDAC1 Confers Resistance to Ferroptosis in Colorectal Cancer. · Adv Sci (Weinh) (2025)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cusabio | T094-109916-01 | CSB-RA299884A0HU | HDAC1 Recombinant Monoclonal Antibody | Rabbit | Monoclonal | Human | ELISA, WB | 50μl, 100μl | |
| Biosynth | F502-120679-01 | 70R-17704 | HDAC1 antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, IHC, IF, WB | 50 ul | |
| Biosynth | F502-126693-01 | 70R-31223 | HDAC1 antibody | Rabbit | Polyclonal | HDAC1 antibody detects endogenous levels of total HDAC1 protein; Cross: Mouse, Rat | WB, IHC, IF, ELISA | 0.1 mg | |
| Biosynth | F502-104636-01 | 10R-4302 | HDAC1 antibody | Mouse | Monoclonal | Human; Cross: Human, Dog, Rat, Monkey | FC, IF, WB | 100 ul | |
| Biosynth | F502-128633-01 | 70R-33395 | HDAC1 antibody (Ser421) | Rabbit | Polyclonal | HDAC1 antibody detects endogenous levels of HDAC1 only when phosphorylated at serine 421; Cross: Mouse | WB, ELISA | 0.1 mg | |
| Biosynth | F502-104637-01 | 10R-4304 | HDAC1 antibody | Mouse | Monoclonal | Human; Cross: Human | FC, IF, WB | 100 ul | |
| Biosynth | F502-128634-01 | 70R-33396 | HDAC1 antibody | Rabbit | Polyclonal | HDAC1 antibody detects endogenous levels of total HDAC1 protein; Cross: Mouse | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-104635-01 | 10R-4301 | HDAC1 antibody | Mouse | Monoclonal | Human; Cross: Human | FC, IF, WB | 100 ul | |
| Biosynth | F502-132358-01 | 70R-37435 | HDAC1 antibody (Ser421/423) | Rabbit | Polyclonal | Human; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Cloud-Clone | T813-123324-01 | PAC206Hu01 | Polyclonal Antibody to Histone Deacetylase 1 (HDAC1) | Rabbit | Polyclonal | Human | WB; ICC/IF | 100µl | |
| Cloud-Clone | T813-123326-01 | PAC206Mu02 | Polyclonal Antibody to Histone Deacetylase 1 (HDAC1) | Rabbit | Polyclonal | Murine | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-113884-01 | MAC206Hu22 | Monoclonal Antibody to Histone Deacetylase 1 (HDAC1) | Mouse | Monoclonal | Human | WB; IHC; ICC/IF; FCM | 100µl | |
| Cloud-Clone | T813-123325-01 | PAC206Mu01 | Polyclonal Antibody to Histone Deacetylase 1 (HDAC1) | Rabbit | Polyclonal | Murine | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-113885-01 | MAC206Ra21 | Monoclonal Antibody to Histone Deacetylase 1 (HDAC1) | Mouse | Monoclonal | Rat | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-123327-01 | PAC206Ra01 | Polyclonal Antibody to Histone Deacetylase 1 (HDAC1) | Rabbit | Polyclonal | Rat | WB; IHC; ICC; IP. | 100µl | |
| MyBioSource | R247-151587-01 | MBS440062 | HDAC1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB | 0.2 mg | |
| MyBioSource | R247-137693-01 | MBS2538421 | HDAC1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; ELISA | 0.02 mL | |
| MyBioSource | R247-137853-01 | MBS2542378 | HDAC1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA; IHC | ||
| Biosynth | F502-100777-01 | 10-3027 | HDAC1 Antibody | Mouse | Monoclonal | Human; Cross: Mouse, Rat, Human | Flow Cyt, IHC-P, WB, IP, ChIP, ICC/IF | 0.1 mg | |
| Biosynth | F502-113137-01 | 61-1117 | HDAC1 Antibody (FITC) | Mouse | Human; Cross: Mouse, Human | Flow Cyt, ICC/IF | 0.05 mg | ||
| ELK Biotechnology | T376-119052-01 | ES2498 | HDAC1 rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;IHC;IF;ELISA | 50μL | |
| MyBioSource | R247-148121-01 | MBS375133 | HDAC1, Monoclonal Antibody | Mouse | Monoclonal | Human, Mouse, Rat | FC/FACS; WB; ICC; IF; IP; ChIP; Immunohistochemistry (IHC) Paraffin | 0.1 mg | |
| MyBioSource | R247-148139-01 | MBS375262 | HDAC1, Monoclonal Antibody | Mouse | Monoclonal | Human, Mouse, Rat | FC/FACS; ICC; IF | 0.05 mg |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
HDAC2
p75NTR negatively regulates cell cycle via SC1
MECP2
Loss of MECP2 binding ability to 5mC-DNA
HDAC3
p75NTR negatively regulates cell cycle via SC1
BDNF
Loss of MECP2 binding ability to 5mC-DNA
RBBP4
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
EP300
STAT3 nuclear events downstream of ALK signaling
TFDP1
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
CREB1
MECP2 regulates transcription of neuronal ligands