FAS가 암호화하는 단백질은 종양괴사인자 수용체(TNF receptor) 슈퍼패밀리(superfamily)에 속하며 사멸 도메인(death domain)을 지녀, 세포예정사(programmed cell death)의 생리적 조절에 중심적인 역할을 하고 여러 악성종양 및 면역계 질환의 발병과도 연관되어 있다. 이 수용체가 리간드와 결합하면 FADD, caspase 8, caspase 10을 포함하는 사멸 유도 신호 복합체(death-inducing signaling complex)가 형성되며, 복합체 내 caspase의 자가단백질분해가 하위 caspase 연쇄반응을 일으켜 세포자멸사(apoptosis)로 이어진다. 또한 NF-κB, MAPK3/ERK1, MAPK8/JNK를 활성화하고 정상 이배체 섬유아세포(fibroblast)와 T 세포의 증식 신호 전달에 관여하며, 막관통 도메인이 결여된 아이소폼(isoform)은 전장 이소형이 매개하는 세포자멸사를 음성 조절할 수 있다.
CASP8 activity is inhibitedCaspase activation via Death Receptors in the presence of ligandDimerization of procaspase-8FasL/ CD95L signalingRIPK1-mediated regulated necrosisRegulation by c-FLIPTP53 Regulates Transcription of Death Receptors and Ligands
autoimmune lymphoproliferative syndrome type 1autoimmune lymphoproliferative syndrometumor necrosis factor receptor superfamily member 6 measurementlymphoid neoplasmchronic lymphocytic leukemialymphomaerythrocyte counterythrocyte volume
The minimum detectable dose of rat FAS is typically less than 0.195 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
The minimum detectable dose of human FAS is typically less than 0.31 ng/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
