EIF4A1 — 카탈로그 44건
Gene EIF4A1
NCBI Gene 1973
국내 소싱 가능
44건
유전자 개요
이 유전자는 이중 가닥 RNA 결합 활성과 번역 개시 인자 활성을 가능하게 한다. 세포질 번역 개시와 RNA 중합효소 II에 의한 전사의 양성 조절에 관여한다. 핵 스트레스 과립, 세포질의 핵주위 영역, 그리고 세포막에 위치한다.
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SDeadenylation of mRNAGTP hydrolysis and joining of the 60S ribosomal subunitISG15 antiviral mechanismL13a-mediated translational silencing of Ceruloplasmin expressionM-decay: degradation of maternal mRNAs by maternally stored factorsRibosomal scanning and start codon recognitionTranslation initiation complex formationZ-decay: degradation of maternal mRNAs by zygotically expressed factors
neurodegenerative diseasesex hormone-binding globulin measurementlow density lipoprotein cholesterol measurementtotal cholesterol measurementtriglycerides to phosphoglycerides ratio serum albumin amountapolipoprotein B measurementplatelet count
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Modulation of RNA Condensation by the DEAD-Box Protein eIF4A. · Cell (2020)IGF2BP2 Drives Cell Cycle Progression in Triple-Negative Breast Cancer by Recruiting EIF4A1 to Promote the m6A-Modified CDK6 Translation Initiation Process. · Adv Sci (Weinh) (2024)Over-expression of human cytomegalovirus miR-US25-2-3p downregulates eIF4A1 and inhibits HCMV replication. · FEBS Lett (2013)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
EIF4E
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
EIF4A2
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
EIF4B
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
EIF4A3
Z-decay: degradation of maternal mRNAs by zygotically expressed factors
EIF4EBP1
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
RPS15
Ribosomal scanning and start codon recognition
RPS3
Ribosomal scanning and start codon recognition
RPS23
Ribosomal scanning and start codon recognition