B 림프구에서 엡스타인-바 바이러스(Epstein-Barr virus) 감염에 의해 유도된 발현으로 이 유전자가 확인되었다. 이 유전자는 조혈모세포 수용체(hematopoietin receptor) 계열에 속하는 분비성 당단백질(secreted glycoprotein)을 암호화하며, 28 kDa 단백질과 이합체(heterodimerizes)를 형성하여 인터루킨 27(interleukin 27, IL-27)을 만든다. IL-27은 CD4+ T 세포의 Jak/STAT 경로 활성화를 통해 T 세포 및 염증 반응을 조절한다.
Interleukin-27 signalingInterleukin-35 Signalling
neurodegenerative diseaselevel of interleukin-27 subunit beta in blood serumblood protein amountinterleukin-27 measurementinterleukin 27 receptor subunit alpha measurementprotein measurementneoplasmasthma
The minimum detectable dose of human EBI3 is typically less than 3.9 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
