E2F1 — 카탈로그 19건
Gene E2F1
NCBI Gene 1869
국내 소싱 가능
19건
유전자 개요
이 유전자는 전사인자(transcription factor) E2F 계열 단백질을 암호화한다. E2F 계열은 세포 주기(cell cycle) 조절 및 종양(tumor) 억제 단백질 기능에 핵심적인 역할을 하며, 작은 DNA 종양 바이러스의 형질전환 단백질 표적이 되기도 한다. 이 단백질은 세포 주기 의존적인 방식으로 망막모세포종(retinoblastoma) 단백질 pRB와 우선적으로 결합하며, 세포 증식과 p53 의존적/독립적 세포자멸사(apoptosis)를 매개할 수 있다.
Activation of NOXA and translocation to mitochondriaActivation of PUMA and translocation to mitochondriaCyclin A:Cdk2-associated events at S phase entryCyclin D associated events in G1Cyclin E associated events during G1/S transition Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)G1/S-Specific TranscriptionG2 PhaseInhibition of replication initiation of damaged DNA by RB1/E2F1Oncogene Induced Senescence
body heightbenign prostatic hyperplasiasex hormone-binding globulin measurementneurodegenerative diseaseRed cell distribution widthreticulocyte countsmoking status measurementprostate specific antigen amount
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) E2F1 pathways to apoptosis. · FEBS Lett (2002)Human ARF binds E2F1 and inhibits its transcriptional activity. · Oncogene (2001)E2F-1 induced apoptosis. · Apoptosis (2001)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Cusabio | T094-110125-01 | CSB-RA826096A0HU | E2F1 Recombinant Monoclonal Antibody | Rabbit | Monoclonal | Human, Rat | ELISA, WB, IHC, IF, FC | 50μl, 100μl | |
| Biosynth | F502-126324-01 | 70R-30886 | E2F1 antibody | Rabbit | Polyclonal | E2F1 antibody detects endogenous levels of total E2F1 protein; Cross: Mouse | WB, ELISA | 0.1 mg | |
| Biosynth | F502-117419-01 | 70R-14098 | E2F1 antibody | Rabbit | Polyclonal | Human | WB | 0.1 mg | |
| Biosynth | F502-115401-01 | 70R-10490 | E2F1 antibody | Rabbit | Polyclonal | Human; Cross: Predicted: Human, Mouse, Rat, Dog, Guinea Pig, Horse, Rabbit | WB | 100 ul | |
| Biosynth | F502-126323-01 | 70R-30885 | E2F1 antibody (Thr433) | Rabbit | Polyclonal | E2F1 antibody detects endogenous levels of E2F1 only when phosphorylated at threonine 433; Cross: Mouse | WB, ELISA | 0.1 mg | |
| Biosynth | F502-134049-01 | 70R-49677 | E2F1 antibody | Rabbit | Polyclonal | Recognizes endogenous levels of E2F1 protein; Cross: Mouse, Rat, Monkey | WB | 100 ul | |
| Biosynth | F502-119885-01 | 70R-16974 | E2F1 antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, IHC, WB | 50 ul | |
| Biosynth | F502-116882-01 | 70R-13512 | E2F1 antibody | Rabbit | Polyclonal | Human, Mouse | IF, ICC, WB | 100 ul | |
| Cloud-Clone | T813-115521-01 | MAJ181Hu21 | Monoclonal Antibody to E2F Transcription Factor 1 (E2F1) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-127549-01 | PAJ181Hu01 | Polyclonal Antibody to E2F Transcription Factor 1 (E2F1) | Rabbit | Polyclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| MyBioSource | R247-201035-01 | MBS9202865 | E2F1, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB; ELISA | 0.08 mL | |
| MyBioSource | R247-156206-01 | MBS5312404 | E2F1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse | IF; ICC; WB | 0.1 mL | |
| MyBioSource | R247-124212-01 | MBS190136 | E2F-1 (E2F1), Monoclonal Antibody | Mouse | Monoclonal | Human | Immunoblot; Immunoprecipitation | 0.1 mg | |
| Biosynth | F502-109524-01 | 20R-2760 | E2F-1 antibody | Rabbit | Human; Cross: Human, Mouse | WB | 0.05 mg | ||
| ELK Biotechnology | T376-120335-01 | ES5036 | E2F-1 (phospho Thr433) rabbit pAb | Rabbit | Polyclonal | Human;Mouse | WB;ELISA | 50μL |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
TFDP1
Activation of NOXA and translocation to mitochondria
CDK2
G2 Phase
TP53
Activation of NOXA and translocation to mitochondria
RB1
Inhibition of replication initiation of damaged DNA by RB1/E2F1
RBBP4
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
CDKN1A
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CCNE1
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
CDKN1B
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest