CUL2 — 카탈로그 30건
Gene CUL2
NCBI Gene 8453
국내 소싱 가능
30건
유전자 개요
이 유전자는 유비퀴틴 연결효소 복합체(ubiquitin ligase complex)의 골격 활성과 유비퀴틴 단백질 연결효소(ubiquitin protein ligase) 결합 활성을 부여한다. C-말단 분해 신호(C-end degron) 규칙 경로를 통해 유비퀴틴 의존적 단백질 분해 과정에 관여한다. 핵질에 위치하며, Cul2-RING 유비퀴틴 연결효소 복합체의 일부이다.
Antigen processing: Ubiquitination & Proteasome degradationNeddylationOxygen-dependent proline hydroxylation of Hypoxia-inducible Factor AlphaRegulation of expression of SLITs and ROBOsRibosome Quality Control (RQC) complex extracts and degrades nascent peptide
Crohn's diseaseinflammatory bowel diseaseeosinophil countstrand of hair colortriglyceride measurementobesityskin diseaseAlzheimer disease
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) von Hippel-Lindau disease. · Medicine (Baltimore) (1997)circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2. · Mol Cancer (2020)A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation. · Science (2019)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
HIF1A
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
PSMA1
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
PSMA3
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
EGLN1
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
HIF3A
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
EGLN2
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
PSMD14
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
PSMC5
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha