CTBP1 — 카탈로그 13건
Gene CTBP1
NCBI Gene 1487
국내 소싱 가능
13건
유전자 개요
CTBP1 유전자는 아데노바이러스(adenovirus) E1A 단백질의 C-말단(C-terminus)에 결합하는 인단백질(phosphoprotein)을 암호화하며, 이 인단백질은 전사 억제인자(transcriptional repressor)로서 세포 증식(cellular proliferation)에 관여할 수 있다. 해당 단백질은 밀접하게 관련된 CTBP2 유전자의 산물과 이량체(dimer)를 형성하고, 폴리콤 군 단백질 복합체(polycomb group protein complex)와 상호작용하여 발달 과정에서 유전자 발현(gene expression)을 조절한다. 또한 이 유전자 전사체의 선택적 스플라이싱(alternative splicing)은 여러 전사체 변이체(transcript variants)를 생성한다.
Deactivation of the beta-catenin transactivating complexNegative Regulation of CDH1 Gene TranscriptionRepression of WNT target genesSUMOylation of transcription cofactorsSignaling by TCF7L2 mutants
hypotonia, ataxia, developmental delay, and tooth enamel defect syndromeHbA1c measurementblood glucose amountheart rategenetic disorderDrugs used in diabetes use measurementtype 2 diabetes mellitusglucose measurement
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) The Role of CtBP1 in Oncogenic Processes and Its Potential as a Therapeutic Target. · Mol Cancer Ther (2017)The evolving epigenome. · Hum Mol Genet (2013)Components of the CtBP1/BARS-dependent fission machinery. · Histochem Cell Biol (2013)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| MyBioSource | R247-212177-01 | MBS9600568 | CTBP1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| Biosynth | F502-115920-01 | 70R-12607 | CtBP1 antibody | Rabbit | Polyclonal | Human | IF, ICC, WB | 100 ul | |
| Biosynth | F502-103172-01 | 10R-1770 | CTBP1 antibody | Mouse | Monoclonal | Human; Cross: To be determined by end-user. | ELISA, WB | 100 ul | |
| Biosynth | F502-119521-01 | 70R-16640 | CTBP1 antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, IHC, WB | 50 ul | |
| Biosynth | F502-129833-01 | 70R-34496 | CtBP1 antibody (Ser422) | Rabbit | Polyclonal | CtBP1 antibody detects endogenous levels of CtBP1 only when phosphorylated at serine 422; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-129834-01 | 70R-34497 | CtBP1 antibody | Rabbit | Polyclonal | CtBP1 antibody detects endogenous levels of total CtBP1 protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-117427-01 | 70R-14107 | CTBP1 antibody | Rabbit | Polyclonal | Human | WB, IHC-P | 0.1 mg | |
| Cloud-Clone | T813-123629-01 | PAC409Hu01 | Polyclonal Antibody to C-Terminal Binding Protein 1 (CTBP1) | Rabbit | Polyclonal | Human | WB | 100µl | |
| MyBioSource | R247-136747-01 | MBS2518095 | CTBP1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA; WB; IHC | 0.02 mL | |
| MyBioSource | R247-190920-01 | MBS8226669 | CTBP1, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat, Porcine | WB; IHC; IF; ICC | 0.03 mL | |
| ELK Biotechnology | T376-120272-01 | ES4883 | CtBP1 rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat | WB;IHC;IF;ELISA | 50μL |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
CTBP2
Signaling by TCF7L2 mutants
HDAC1
Repression of WNT target genes
MYC
Repression of WNT target genes
AXIN2
Repression of WNT target genes
AKT1
Deactivation of the beta-catenin transactivating complex
AKT2
Deactivation of the beta-catenin transactivating complex
SOX9
Deactivation of the beta-catenin transactivating complex
SOX2
Deactivation of the beta-catenin transactivating complex