CRKL — 카탈로그 19건
Gene CRKL
NCBI Gene 1399
국내 소싱 가능
19건
유전자 개요
이 유전자는 SH2 및 SH3 (src 상동성) 도메인을 포함하는 단백질 키나아제(protein kinase)를 암호화한다. 이 키나아제는 RAS 및 JUN 키나아제 신호 전달 경로를 활성화하고 RAS 의존적으로 섬유아세포(fibroblast)를 형질 전환시키는 것으로 알려져 있다. 또한 BCR-ABL 타이로신 키나아제(tyrosine kinase)의 기질(substrate)이며, BCR-ABL에 의한 섬유아세포 형질 전환에 관여하고 종양 유전(oncogenic)으로서 기능할 수 있다.
Downstream signal transductionErythropoietin activates RASFrs2-mediated activationMET activates RAP1 and RAC1MET receptor recyclingRegulation of signaling by CBL
neurodegenerative diseaseplatelet volumelymphocyte countplatelet counthepatocellular carcinomagastric cancerneoplasmcancer
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Tracking cancer drugs in living cells by thermal profiling of the proteome. · Science (2014)Isolation and chromosomal localization of CRKL, a human crk-like gene. · Oncogene (1993)Hypoxia-induced up-regulation of VASP promotes invasiveness and metastasis of hepatocellular carcinoma. · Theranostics (2018)
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| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| Biosynth | F502-126466-01 | 70R-31015 | CrkL antibody (Tyr207) | Rabbit | Polyclonal | CrkL antibody detects endogenous levels of CrkL only when phosphorylated at tyrosine 207; Cross: Mouse | WB, IHC, IF, ELISA | 0.1 mg | |
| Biosynth | F502-102659-01 | 10R-10953 | CRKL antibody | Mouse | Monoclonal | Human | WB, FC, ELISA | 0.1 mg | |
| Biosynth | F502-132353-01 | 70R-37430 | CrkL antibody (Tyr207) | Rabbit | Polyclonal | Human; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-126467-01 | 70R-31016 | CrkL antibody | Rabbit | Polyclonal | CrkL antibody detects endogenous levels of total CrkL protein; Cross: Mouse | WB, IHC, IF, ELISA | 0.1 mg | |
| Cloud-Clone | T813-126978-01 | PAG766Mu02 | Polyclonal Antibody to Crk Like Protein (CRKL) | Rabbit | Polyclonal | Murine | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-115259-01 | MAG766Hu21 | Monoclonal Antibody to Crk Like Protein (CRKL) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-126976-01 | PAG766Hu01 | Polyclonal Antibody to Crk Like Protein (CRKL) | Rabbit | Polyclonal | Human | WB; IHC | 100µl | |
| Cloud-Clone | T813-126977-01 | PAG766Mu01 | Polyclonal Antibody to Crk Like Protein (CRKL) | Rabbit | Polyclonal | Murine | WB; IHC; ICC; IP. | 100µl | |
| MyBioSource | R247-137106-01 | MBS2525825 | CRKL, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | ELISA; WB; IHC | 0.02 mL | |
| ELK Biotechnology | T376-117223-01 | ES1517 | Crk-L (phospho Tyr207) rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat;Monkey | WB;IHC;IF;ELISA | 50μL | |
| ELK Biotechnology | T376-118772-01 | ES2053 | Crk-L rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat;Monkey | WB;IHC;IF;ELISA | 50μL |