CHRNA5 — 카탈로그 18건
Gene CHRNA5
NCBI Gene 1138
국내 소싱 가능
18건
유전자 개요
이 유전자는 리간드-개폐 이온 통로(ligand-gated ion channels) 초과다중친족의 일원이자 니코틴성 아세틸콜린 수용체(nicotinic acetylcholine receptor) 소단위를 암호화한다. 이들은 시냅스에서 빠른 신호 전달을 매개하며, 별도이지만 유사한 소단위로 구성된 헤테로펜타머(heteropentamer)라고 생각된다. 이 유전자의 결함은 폐암 유형 2(lung cancer type 2)에 대한 감수성과 연관되어 있다.
Highly calcium permeable nicotinic acetylcholine receptorsHighly calcium permeable postsynaptic nicotinic acetylcholine receptors
lung carcinomachronic obstructive pulmonary diseaselung adenocarcinomalung cancerchronic bronchitissmoking behavior traitbronchus cancerrespiratory system cancer
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Mechanisms of Nicotine Addiction. · Cold Spring Harb Perspect Med (2021)Association of the CHRNA5-A3-B4 gene cluster with heaviness of smoking: a meta-analysis. · Nicotine Tob Res (2011)Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. · Nat Genet (2022)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| MyBioSource | R247-213595-01 | MBS9607242 | CHRNA5, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; ELISA | 0.1 mL | |
| Biosynth | F502-118062-01 | 70R-1529 | CHRNA5 antibody | Rabbit | Polyclonal | Human; Cross: Predicted: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish | WB | 100 ul | |
| Biosynth | F502-119271-01 | 70R-16409 | CHRNA5 antibody | Rabbit | Polyclonal | Human; Cross: Human, Mouse, Rat | ELISA, WB | 50 ul | |
| Biosynth | F502-133911-01 | 70R-49551 | CHRNA5 antibody | Rabbit | Polyclonal | Recognizes endogenous levels of CHRNA5 protein; Cross: Mouse, Rat, Bovine, Chicken, Monkey | WB | 100 ul | |
| Cloud-Clone | T813-114378-01 | MAD142Hu21 | Monoclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 5 (CHRNa5) | Mouse | Monoclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| Cloud-Clone | T813-124743-01 | PAD142Hu01 | Polyclonal Antibody to Cholinergic Receptor, Nicotinic, Alpha 5 (CHRNa5) | Rabbit | Polyclonal | Human | WB; IHC; ICC; IP. | 100µl | |
| MyBioSource | R247-135014-01 | MBS243307 | CHRNA5, Polyclonal Antibody | Goat | Polyclonal | Human, Monkey, Pig, Hamster, Horse | Immunohistochemistry (IHC - Paraffin); WB; ELISA | 0.05 mg | |
| Biosynth | F502-138931-01 | 70R-8064 | CHRNA5 antibody | Rabbit | Polyclonal | Human; Cross: Predicted: Human, Mouse, Rat, Cow, Dog, Horse, Pig, Rabbit | WB | 100 ul | |
| ELK Biotechnology | T376-117482-01 | ES1583 | AChRα5 rabbit pAb | Rabbit | Polyclonal | Human;Mouse;Rat;Monkey | WB;ELISA | 50μL |
관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
CHRNA4
Highly calcium permeable nicotinic acetylcholine receptors
CHRNA1
Highly calcium permeable nicotinic acetylcholine receptors
CHRNA2
Highly calcium permeable nicotinic acetylcholine receptors
CHRNA3
Highly calcium permeable nicotinic acetylcholine receptors
CHRNB2
Highly calcium permeable nicotinic acetylcholine receptors
CHRNA7
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors