취급 제조사 2곳
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유전자 개요
CHK2(CHEK2)가 암호화하는 단백질은 세포 주기(cell cycle) 체크포인트 조절자이자 추정 종양 억제자로, DNA 손상과 복제(replication) 차단에 반응하여 세포 주기 진행을 정지시킨다. 활성화되면 CDC25C 인산 가수 분해 효소(phosphatase)를 억제해 유사분열(mitosis) 진입을 막고 p53을 안정화하여 G1기 정지를 유도하며, BRCA1과 결합·인산화하여 DNA 손상 후 생존 회복을 돕는다. 이 핵 단백질의 돌연변이는 Li-Fraumeni 증후군 및 육종·유방암(breast cancer)·뇌종양 소인과 연관되며, 세린/트레오닌 단백질 키나아제의 CDS1 서브패밀리(subfamily)에 속한다.
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- 대표 논문 (PubMed) The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. · Adv Cancer Res (2010)CHK2 kinase--a busy messenger. · Nat Rev Mol Cell Biol (2001)The Chk2 protein kinase. · DNA Repair (Amst) (2004)
체크박스로 여러 제품을 선택해 한 번에 견적을 요청하세요. 제조사·Cat No·Application을 한 표에서 비교합니다.
| 견적 | 제조사 | Cat No | Mfr No | 제품명 | Host | Clonality | Reactivity | Application | Size |
|---|---|---|---|---|---|---|---|---|---|
| MyBioSource | R247-154520-01 | MBS4761265 | Chk2, Monoclonal Antibody | Rabbit | Monoclonal | Human | WB; IP | 0.1 mL | |
| MyBioSource | R247-165518-01 | MBS6267641 | Chk2, Monoclonal Antibody | Mouse | Monoclonal | Human | IF; IP; WB | 0.1 mL | |
| MyBioSource | R247-165489-01 | MBS6266519 | Chk2, Monoclonal Antibody | Mouse | Monoclonal | Human | IF; IP; WB | 0.1 mL | |
| MyBioSource | R247-165495-01 | MBS6266743 | Chk2, Monoclonal Antibody | Mouse | Monoclonal | Human | IF; IP; WB | 0.1 mL | |
| MyBioSource | R247-165523-01 | MBS6267865 | Chk2, Monoclonal Antibody | Mouse | Monoclonal | Human | IF; IP; WB | 0.1 mL | |
| MyBioSource | R247-165501-01 | MBS6266968 | Chk2, Monoclonal Antibody | Mouse | Monoclonal | Human | IF; IP; WB | 0.1 mL | |
| MyBioSource | R247-165480-01 | MBS6266295 | Chk2, Monoclonal Antibody | Mouse | Monoclonal | Human | IF; IP; WB | 0.1 mL | |
| MyBioSource | R247-209755-01 | MBS9435758 | Chk2, Monoclonal Antibody | Rabbit | Monoclonal | Human | WB; ICC; IF; IHC; IP | 0.05 mL | |
| MyBioSource | R247-165473-01 | MBS6266071 | Chk2, Monoclonal Antibody | Mouse | Monoclonal | Human | IF; IP; WB | 0.1 mL | |
| MyBioSource | R247-165507-01 | MBS6267193 | Chk2, Monoclonal Antibody | Mouse | Monoclonal | Human | IF; IP; WB | 0.1 mL | |
| MyBioSource | R247-212221-01 | MBS9600806 | Chk2, Polyclonal Antibody | Rabbit | Polyclonal | Human, Mouse, Rat | WB; IHC; IF; ICC; ELISA | 0.1 mL | |
| MyBioSource | R247-165467-01 | MBS6265847 | Chk2, Monoclonal Antibody | Mouse | Monoclonal | Human | IF; IP; WB | 0.1 mL | |
| MyBioSource | R247-165512-01 | MBS6267417 | Chk2, Monoclonal Antibody | Mouse | Monoclonal | Human | IF; IP; WB | 0.1 mL | |
| MyBioSource | R247-210370-01 | MBS9456699 | Chk2, Monoclonal Antibody | Rabbit | Monoclonal | Human | Most Applications | 0.1 mL | |
| MyBioSource | R247-165528-01 | MBS6268089 | Chk2, Monoclonal Antibody | Mouse | Monoclonal | Human | IF; IP; WB | 0.1 mL | |
| Biosynth | F502-135898-01 | 70R-51364 | CHK2 antibody | Rabbit | Polyclonal | Recognizes endogenous levels of CHK2 protein; Cross: Rat | WB | 100 ul | |
| Biosynth | F502-128623-01 | 70R-33386 | Chk2 antibody (Thr383) | Rabbit | Polyclonal | Chk2 antibody detects endogenous levels of Chk2 only when phosphorylated at threonine 383; Cross: Mouse, Rat | WB, IF, ELISA | 0.1 mg | |
| Biosynth | F502-131643-01 | 70R-36668 | Chk2 antibody (Ser516) | Rabbit | Polyclonal | Chk2 antibody (Ser516) detects endogenous levels of Chk2 only when phosphorylated at serine 516 | WB, ELISA | 0.1 mg | |
| Biosynth | F502-132042-01 | 70R-37142 | Chk2 antibody (Thr68) | Rabbit | Polyclonal | Chk2 antibody (Thr68) detects endogenous levels of Chk2 only when phosphorylated at threonine 68; Cross: Mouse, Rat | WB, IHC | 0.1 mg | |
| Biosynth | F502-130267-01 | 70R-34982 | Chk2 antibody (Thr68) | Rabbit | Polyclonal | Chk2 Antibody detects endogenous levels of Chk2 only when phosphorylated at Threonine 68; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-132350-01 | 70R-37428 | CHK2 antibody (Thr387) | Rabbit | Polyclonal | Human; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-117157-01 | 70R-13798 | CHK2 antibody | Rabbit | Polyclonal | Human | WB | 0.1 mg | |
| Biosynth | F502-132456-01 | 70R-37527 | Chk2 antibody | Rabbit | Polyclonal | Human; Cross: Mouse, Rat | WB, IHC | 0.1 mg | |
| Biosynth | F502-126305-01 | 70R-30869 | Chk2 antibody (Thr387) | Rabbit | Polyclonal | Chk2 antibody detects endogenous levels of Chk2 only when phosphorylated at threonine 387; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-103364-01 | 10R-1978 | CHK2 antibody | Mouse | Monoclonal | Human; Cross: Human | ELISA, IF, IHC, WB | 100 ul | |
| Biosynth | F502-128624-01 | 70R-33387 | Chk2 antibody | Rabbit | Polyclonal | Chk2 antibody detects endogenous levels of total Chk2 protein; Cross: Mouse, Rat | IHC, ELISA | 0.1 mg | |
| Biosynth | F502-131651-01 | 70R-36675 | Chk2 antibody | Rabbit | Polyclonal | Chk2 antibody detects endogenous levels of total Chk2 protein; Cross: Mouse, Rat | WB, IHC ELISA | 0.1 mg | |
| Biosynth | F502-126307-01 | 70R-30870 | Chk2 antibody | Rabbit | Polyclonal | Chk2 antibody detects endogenous levels of total Chk2 protein; Cross: Mouse, Rat | WB, IHC, ELISA | 0.1 mg | |
| Biosynth | F502-135338-01 | 70R-50855 | CHK2 antibody | Rabbit | Polyclonal | Recognizes endogenous levels of CHK2 protein; Cross: Pig | WB, IHC, IF, ICC | 100 ul | |
| Biosynth | F502-132312-01 | 70R-37393 | Chk2 antibody (Ser33) | Rabbit | Polyclonal | Human | IHC | 0.1 mg | |
| Biosynth | F502-132132-01 | 70R-37225 | Chk2 antibody (Ser516) | Rabbit | Polyclonal | Chk2 antibody (Ser516) detects endogenous levels of Chk2 only when phosphorylated at serine 516 | WB | 0.1 mg | |
| Biosynth | F502-130356-01 | 70R-35095 | Chk2 antibody | Rabbit | Polyclonal | Chk2 antibody detects endogenous levels of total Chk2 protein; Cross: Mouse, Rat | WB, ELISA | 0.1 mg | |
| MyBioSource | R247-210670-01 | MBS9468211 | Chk2, Recombinant Antibody | Rabbit | Monoclonal | Human | WB; IP | 0.05 mL | |
| MyBioSource | R247-196735-01 | MBS8602560 | Chk2, Monoclonal Antibody | Rabbit | Monoclonal | Human | WB; ICC; IF; IP | 0.1 mL | |
| MyBioSource | R247-212597-01 | MBS9602737 | CHK2, Monoclonal Antibody | Mouse | Monoclonal | Human | WB; IHC; IF; ICC; ELISA | 0.05 mL | |
| MyBioSource | R247-139080-01 | MBS2572614 | Chk2, Monoclonal Antibody | Rabbit | Monoclonal | Human | WB | 0.05 mL | |
| MyBioSource | R247-207738-01 | MBS9401478 | CHK2, Polyclonal Antibody | Rabbit | Polyclonal | Human | WB | 0.1 mL | |
| MyBioSource | R247-192124-01 | MBS830523 | CHK2, Monoclonal Antibody | Mouse | Monoclonal | Human | ELISA; IF; IHC; WB | 0.1 mL | |
| MyBioSource | R247-210736-01 | MBS9469817 | Chk2, Recombinant Antibody | Rabbit | Monoclonal | Human | WB; IHC; ICC; IF; IP | 0.05 mL | |
| MyBioSource | R247-154168-01 | MBS460223 | Chk2, Monoclonal Antibody | Mouse | Monoclonal | Human | ELISA; FC/FACS; IHC; IP; WB | 0.1 mg | |
| MyBioSource | R247-195051-01 | MBS8538433 | CHK2, Monoclonal Antibody | Mouse | Monoclonal | Human | WB; IHC; ICC; FC/FACS; ELISA | 0.1 mL | |
| MyBioSource | R247-196734-01 | MBS8602559 | Chk2, Monoclonal Antibody | Rabbit | Monoclonal | Human | WB; ICC; IF; IP | 0.1 mL | |
| Biosynth | F502-108814-01 | 20R-2000 | Chk2 antibody | Rabbit | Human; Cross: Human, Mouse, Rat | WB | 0.05 mg | ||
| Biosynth | F502-109099-01 | 20R-2294 | Chk2 antibody | Rabbit | Human | WB | 0.05 mg | ||
| MyBioSource | R247-194845-01 | MBS8533967 | Chk2, Monoclonal Antibody | Rabbit | Monoclonal | Human | WB; ICC; IF; IHC; IP | 0.1 mL | |
| MyBioSource | R247-194047-01 | MBS850536 | CHK2, Monoclonal Antibody | Mouse | Monoclonal | Human | WB; IHC; IF; ELISA | 0.1 mg | |
| MyBioSource | R247-119949-01 | MBS1569108 | Phospho-CHK2, Recombinant Antibody | Mouse | Monoclonal | Human | IHC; IP; WB | 0.1 mg |