CHEK1 — 카탈로그 13건
Gene CHEK1
NCBI Gene 1111
국내 소싱 가능
13건
Activation of ATR in response to replication stressChk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexG2/M DNA damage checkpointPresynaptic phase of homologous DNA pairing and strand exchangeProcessing of DNA double-strand break endsRegulation of TP53 Activity through PhosphorylationSignaling by SCF-KITTP53 Regulates Transcription of DNA Repair GenesTranscriptional Regulation by E2F6Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
neurodegenerative diseaseoocyte/zygote/embryo maturation arrest 21alopecia areataMale infertility due to gonadal dysgenesis or sperm disorderhereditary neoplastic syndromeInherited cancer-predisposing syndromelymphocyte countnon-small cell lung carcinoma
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer. · Adv Cancer Res (2010)CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma. · Mol Cancer (2021)Human Tra2 proteins jointly control a CHEK1 splicing switch among alternative and constitutive target exons. · Nat Commun (2014)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
CHEK2
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
BRCA1
Transcriptional Regulation by E2F6
ATR
Activation of ATR in response to replication stress
CDC25C
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
RPA1
Activation of ATR in response to replication stress
RPA2
Activation of ATR in response to replication stress
RAD17
Activation of ATR in response to replication stress
ATRIP
Activation of ATR in response to replication stress