CHD3 — 카탈로그 50건
Gene CHD3
NCBI Gene 1107
국내 소싱 가능
50건
유전자 개요
이 유전자는 크로모(염색질 조직화 수정자) 도메인과 SNF2 관련 헬리카아제/ATPase 도메인의 존재를 특징으로 하는 CHD 단백질 계열의 구성원을 암호화합니다. 이 단백질은 히스톤 탈아세틸화 효소 복합체인 Mi-2/NuRD 복합체의 구성 요소로, 히스톤을 탈아세틸화하여 염색질 리모델링에 참여합니다. 염색질 리모델링은 전사를 포함한 여러 과정에 필수적입니다.
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionHDACs deacetylate histonesPotential therapeutics for SARSRNA Polymerase I Transcription InitiationRegulation of PTEN gene transcriptionRegulation of TP53 Activity through AcetylationRegulation of endogenous retroelements by KRAB-ZFP proteinsRegulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)SUMOylation of chromatin organization proteinsTranscriptional regulation of brown and beige adipocyte differentiation by EBF2
Snijders Blok-Campeau syndromegenetic disorderIntellectual disabilitysex hormone-binding globulin measurementtestosterone measurementGlobal developmental delayneurodegenerative diseaseMacrocephaly
데이터 출처 · 근거
- NCBI Gene ↗유전자 정보
- Open Targets ↗질환 연관·생물학적 경로
- 대표 논문 (PubMed) Mi-2/NuRD: multiple complexes for many purposes. · Biochim Biophys Acta (2004)The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism. · Exp Mol Med (2019)CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language. · Nat Commun (2018)
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관련 표적
같은 생물학적 경로를 공유하는 표적 — 함께 검토되는 시약군입니다.
HDAC1
Regulation of TP53 Activity through Acetylation
HDAC2
Regulation of TP53 Activity through Acetylation
MTA2
Regulation of TP53 Activity through Acetylation
RBBP4
Regulation of TP53 Activity through Acetylation
MTA1
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
TP53
Regulation of TP53 Activity through Acetylation
PPARG
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
AKT1
Regulation of TP53 Activity through Acetylation